Prostate Cancer Clinical Trials

What side effects did you experience with prostate cancer surgery vs radiation?

Hello!--To anyone having gone through Prostate Cancer (surgery or radiation)....I'm in between decisions as to what treatment plan to go with and would like to hear experience(s) regarding side affects experienced for both?...Specifically: ..Incontinence, ED, Diarrhea, ...Also, with respect to radiation...damage to other healthy tissues via Brachytherapy or using "Beam" and the extent of that damage?...Thank you in advance!!

What's it like being on active surveillance for recurrent prostate cancer?

I have recurrent prostate cancer after radiation therapy, and my doctor has recommended observation (also called watchful waiting). This means regular check-ups and monitoring instead of starting active treatment right now. The idea is to watch for any symptoms or signs of progression while avoiding more intensive treatments unless they become necessary. I'm trying to understand what this approach looks like in real life and would love to hear from others who have been in a similar situation. • If you've been on observation for recurrent prostate cancer, what has your monitoring schedule been like? • What signs or changes did you and your care team watch for, and how did you manage the uncertainty of waiting?

What to expect after 18 months on Orgovyx treatment?

Orlogolyx be 18 months in February

How do you cope with dormant cancer cells after Stage IV prostate cancer?

I have Stage IVA prostate cancer and recently read about how cancer cells can remain "dormant" or sleeping in the body after treatment. The article explained that these cells can hide in places like bone marrow and potentially reawaken later, which helped me understand why ongoing monitoring and treatment are so important with advanced prostate cancer. This concept of dormant cells is being studied in breast, prostate, lung, and colon cancers. It made me think about the long-term nature of managing advanced cancer and why doctors emphasize continued care even when things seem stable. I'd love to connect with others who have advanced prostate cancer to hear about your experiences. • How do you handle the mental aspect of knowing cancer cells might still be present? • What has your long-term monitoring and treatment journey looked like? Link: https://www.nature.com/articles/d41586-025-04149-3

Are there clinical trials for ERG protein research in prostate cancer?

I have stage IIIB prostate cancer and stay updated on research that might lead to new treatments. I recently read about exciting research on ERG, a protein involved in about half of all prostate cancers. The study found that ERG works by transforming one type of prostate cell (basal cells) into the cancer cells that make up most tumors (luminal cells). The researchers identified specific proteins like STAT3 and enzymes KMT2A and DOT1L as potential targets for future drugs. This could lead to treatments that target cancer at its source rather than just treating existing tumors. I'm interested in clinical trials and wondering if this research might open new opportunities. • Have any of you participated in trials targeting ERG or similar pathways? • What has your experience been with treatments that work differently than standard approaches? Link: https://www.foxchase.org/news/researchers-uncover-how-key-oncogene-drives-prostate-cancer-its-earliest-stage

How are you feeling the day before cancer surgery?

Tomorrow is my surgery ☺️

What factors helped you decide on Stage 4 prostate cancer treatment?

I have Stage IVA prostate cancer and my oncologist has explained several treatment options. These include hormonal therapy alone, hormonal therapy combined with abiraterone, radiation therapy with hormonal treatments, or surgery to remove my prostate and nearby lymph nodes. Some treatments focus on blocking hormones that fuel the cancer, while others directly target or remove cancerous tissue. My doctor will help determine what's most appropriate for my specific situation. I'd love to hear from others who have faced similar decisions about their treatment path. • What factors helped you decide between different treatment approaches? • What has your experience been like with the treatment option you chose?

What's it like taking hormone therapy for recurrent prostate cancer?

I have recurrent prostate cancer and my doctor has prescribed leuprolide as hormone therapy. From what I understand, this medication works by lowering testosterone levels to help control the cancer cells that depend on testosterone to grow. I'm preparing for possible side effects like hot flashes, fatigue, and decreased interest in sex. I'm also aware that long-term use might affect my heart and bones, so I'll need monitoring. I'd really appreciate hearing from others who have been through similar treatment. Your experiences and any practical tips would mean a lot to me. • What was your day-to-day experience like on hormone therapy for prostate cancer? • What advice do you wish someone had given you before starting this treatment?

What are the warning signs of spinal complications from prostate cancer?

I have metastatic prostate cancer that has spread to my bones. I just read about Scott Adams (Dilbert creator) who developed paralysis from spinal involvement as his cancer progressed. This really hit home for me since we have similar diagnoses. His situation shows how quickly things can change when cancer affects areas near the spine. It made me think about the importance of watching for new symptoms and staying on top of monitoring. I'd love to connect with others who have been through similar experiences with advanced prostate cancer. • Have you or someone you know dealt with spinal complications from bone metastases? What was that experience like? • What signs or symptoms made you seek immediate medical attention during your cancer journey? Link: https://www.thegatewaypundit.com/2025/12/dilbert-creator-scott-adams-delivers-heartbreaking-update-hospital/

Has anyone tried Pluvicto treatment for metastatic prostate cancer?

Does anyone have experience in going through pulvicto treatment for metastasize prostate cancer?