Does immunotherapy with chemo cause more fatigue and exhaustion?

Combining immunotherapy with chemotherapy can indeed increase fatigue levels, as the body is working hard to process both treatments while fighting cancer. Many patients in similar situations find that staying hydrated, getting gentle movement when possible, and communicating openly with their care team about energy levels helps manage this exhaustion. Consider sharing what strategies have worked for you or asking others in the community about their experiences with treatment-related fatigue.

I am doing immunotherapy by infusion and a chemo pill every day. This is far less difficult than the first round of the initial chemo therapy. Drinking LOTS of water helps. I get 80 ounces in a day. I also walk every day, trying for 3 miles a day. It isn't fast but it definitely helps with the fatigue. Sometimes I have to do it in 2 or 3 sessions.

Yes, I do go for immunotherapy every other week for colon cancer and yes, it is draining but it gets better after a while. I get cituximab along with magnesium, if needed. I take Capecitabine chemo pills 2 weeks on and 2 weeks off.