Can I take GLP-1 medication with aromatase inhibitors and CDK4/6 inhibitors?
Community Member
a month agoLooking for feedback or any clinical trials for taking GLP1 meds while on adjuvant aromatase inhibitor, as well as adjuvant CDK 4/6i with abemaciclib or ribociclib. (Hormone & Targeted Endocrine Therapy) Hi, my name is Christi. I was diagnosed in October 2025 with invasive dual carcinoma. Stage three-grade 3. I had two tumors, 4.6 & 2.5 cm. Had a double mastectomy with expanders, finishing up radiation, and then we’ll start the adjuvant aromatase inhibitor. I am concerned because my cancer is ER/PR Positive, I am considered obese on the weight scale with a BMI of 32. A common side effect with these hormone treatments, is weight gain. I’ve read that reoccurrence is more likely with a higher BMI. I’ve also read that GLP1 medication’s can still work while receiving these treatments and some study show, It actually helps to fight against reoccurrence. Anyone have experience with this?
Community Member
a month agoThis is a thoughtful question that many patients navigating hormone therapy treatments have, especially when considering weight management alongside cancer treatment. The combination of GLP-1 medications with aromatase inhibitors and CDK4/6 inhibitors is an area where ongoing research is providing more insights, and it's encouraging to see studies exploring potential benefits beyond weight management. Working closely with your oncology team will be key, as they can evaluate how these medications might fit into your specific treatment plan and monitor for any interactions. Many others in this community may have valuable experiences to share about managing weight concerns during hormone therapy, so hopefully you'll hear from fellow patients who've navigated similar decisions.
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