Should I take Kisqali for early-stage breast cancer?

I am 64. I am on letrazole and Kiswahili but I think I want to go off of it. It may decrease my chance of it reoccurring but at what cost? My heart, my lungs , my liver? I feel like things went like a whirlwind to get me started and now that I have had time to research it, I don’t want to take it. Am I wrong?

I have opted not to take for those same reasons. They say it could lower the risk 1-2% of recurrence. I can change my lifestyle to make up that 1-2% reduction.

Exactly. Prayers for you

Letrozole alone not too bad, but Kiswahili would create additional issues

I'm post BMX ER+her2- and on lupron with femara. I'm starting a cdk4/6 inhibitor (Ibrance, Kisquali,Verzenio) the only 3 drugs available in class, but only for 2 years to prevent cancer cell growth. I was node positive. Its a trade off because I was offered 4 rounds chemo but I feel I can benefit from the freedom an oral tablet provides and work with side effects. (Oh also 58y/o and was still premenapause even after hysterectomy at 54!)

Hi Stephanie. I don’t know the details of your cancer but what you can do is go to NCCN guidelines and look for your particular cancer stage and what is recommended. Given your on Lupron I’m assuming you’re younger and that maybe why they are suggesting it. Good Luck

Early stage invasive ductal breast cancer starting radiation in about 2 weeks afterwards they want to give me letrozole I've done a lot of research and I'm kind of skeptical especially the fact that there's bone loss involved and I'm 59 so I'm having second thoughts I may not take it

Hi Daisy ,I also was diagnosed in May 2024 with stage 2 invasive ductal breast cancer .I had a lumpectomy and they also found small amounts in one of 2 lymph nodes .I started anastrozole a year ago and went through 20 sessions of radiation. My side affects were manageable .My Dr explained that my type of cancer was fast growing so she suggested taking kisqali with anastrozole . I have had several side effects but not sure which is causing them .I experienced hot flashes and night sweats but those subsided after a few months.I understand the possible danger to liver and bone loss but I have been tested regularly and there is no evidence of liver damage ,a decrease in white blood cells ( to be expected) ,some kidney change ,but again that is expected.I also have regular EKG tests to see any effect on my heart and all results have been fine.I also had a bone density scan after a year that showed a mild decrease , but that was expected .I am 70 yrs old and hard to know what has caused general arthralgia and fatigue .I find Yoga , water excersise and strength training help me feel better .I take my meds at night and that helps as well .My Dr suggested up to 5000 units of tart cherry supplements for arthralgia and I find that is helping.They are available in chewies or tablets and I take 2000 units . I wish you well on your journey and hope you give the meds some time as your body adjusts .Stay strong , Sarah S

There are much better ways. Lots of natural supplements & compound meds to use with the Letrozole. No side effects with Letrozole thus far, supplements help. Cancer cells feed on sugar just like your good cells. Unfortunately the cancer cells grab the sugar first. Eat parsley & celery leaves to counter those cancer cells from getting the sugar.

All must get their mitochondria healthy, so your body can heal. Drink 1 tablespoon of MCT oil.

Yes, tart Cherry 🍒 Juice aids in fighting off cancer. So sour to drink! The tables sound like a good way.

I take Orserdu with very minor side effects. I attribute that to exercise—/weights twice a week and aerobics 5 times a week. Also weekly acupuncture with ear acupuncture between the weekly treatment. Most folks are not familiar with ear acupuncture. Read about on the web or ask ChatGPT for more info

Hello, I had breast cancer,Her2 negative, ER positive stage 1A. I have had surgery lumpectomy once to remove a 3mm and then a month later another lumpectomy to really clear the margins so that I would not have to have radiation I am on anastrozole 1mg daily. I had my annual mammogram, and it is clear, with No cancer what so ever. My problem is the anastozole, I think I have been putting up with every side effect it comes with. Some days I feel like stopping them. Is there anything else out there that does not have the side effects that anastrozole or perhaps clinical trials etc. I visit with my Oncologist next month for my check up 1 year. I would like to be prepared for this.

This is such a personal and important decision that only you and your medical team can make together. It's completely understandable to have concerns about side effects and want to weigh the benefits carefully, especially with a newly approved treatment. Many people in this community have faced similar decisions about adjuvant therapies and found it helpful to seek a second opinion or ask their oncologist for more detailed information about the specific benefits in their case. Have others here had experience discussing treatment options when the projected benefits feel small compared to potential quality of life impacts?