How do you navigate HER2+ metastatic breast cancer treatment options?

Navigating treatment options in later lines of therapy can feel complex, especially when staying current with emerging approvals and research. Many community members find it helpful to prepare specific questions for oncology appointments about how newer treatments might fit into future treatment planning, even when not immediately applicable. Building a strong communication rhythm with the care team and connecting with others who've walked similar paths often provides valuable perspective on decision-making strategies and staying informed about the evolving HER2+ treatment landscape.

I completely agree about preparing those specific questions for your oncologist - I've found it also helps to ask about clinical trials that might be coming down the pipeline, since staying ahead of potential options has given me more confidence in my treatment planning.

I completely agree about preparing those specific questions for your oncologist - it really does help, and you might also ask them about clinical trials that could be opening up for your situation since the HER2+ landscape is moving so quickly right now.

Hi, Susan, Enhertu has already been used on pre-treated patients that are Her-2 Low so should be even better with regular Her-2 expression (see indication below). I also included another reference below for pre-treated populations. You should definitely start Enhertu - it’s Standard of Care in my oncologist’s practice. FDA Indication: “HER2-low (IHC 1+ or IHC 2+/ISH-) breast cancer, as determined by an FDA-approved test, who have received a prior chemotherapy in the metastatic setting or developed disease recurrence during or within 6 months of completing adjuvant chemotherapy” A previous example Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer Authors: Shanu Modi, M.D., Cristina Saura, M.D., Ph.D., Toshinari Yamashita, M.D., Yeon Hee Park, M.D., Sung-Bae Kim, M.D., Ph.D., Kenji Tamura, M.D., Ph.D., Fabrice Andre, M.D., Ph.D., +18 , for the DESTINY-Breast01 Investigators*Author Info & Affiliations Published December 11, 2019 N Engl J Med 2020;382:610-621 DOI: 10.1056/NEJMoa1914510 VOL. 382 NO. 7 Copyright © 2019 Information & Authors Metrics & Citations View Options References Media Tables Share Abstract BACKGROUND Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate composed of an anti-HER2 (human epidermal growth factor receptor 2) antibody, a cleavable tetrapeptide-based linker, and a cytotoxic topoisomerase I inhibitor. In a phase 1 dose-finding study, a majority of the patients with advanced HER2-positive breast cancer had a response to trastuzumab deruxtecan (median response duration, 20.7 months). The efficacy of trastuzumab deruxtecan in patients with HER2-positive metastatic breast cancer previously treated with trastuzumab emtansine requires confirmation. METHODS In this two-part, open-label, single-group, multicenter, phase 2 study, we evaluated trastuzumab deruxtecan in adults with pathologically documented HER2-positive metastatic breast cancer who had received previous treatment with trastuzumab emtansine. In the first part of the study, we evaluated three different doses of trastuzumab deruxtecan to establish a recommended dose; in the second part, we evaluated the efficacy and safety of the recommended dose. The primary end point was the objective response, according to independent central review. Key secondary end points were the disease-control rate, clinical-benefit rate, duration of response and progression-free survival, and safety. RESULTS Overall, 184 patients who had undergone a median of six previous treatments received the recommended dose of trastuzumab deruxtecan (5.4 mg per kilogram of body weight). In the intention-to-treat analysis, a response to therapy was reported in 112 patients (60.9%; 95% confidence interval [CI], 53.4 to 68.0). The median duration of follow-up was 11.1 months (range, 0.7 to 19.9). The median response duration was 14.8 months (95% CI, 13.8 to 16.9), and the median duration of progression-free survival was 16.4 months (95% CI, 12.7 to not reached). During the study, the most common adverse events of grade 3 or higher were a decreased neutrophil count (in 20.7% of the patients), anemia (in 8.7%), and nausea (in 7.6%). On independent adjudication, the trial drug was associated with interstitial lung disease in 13.6% of the patients (grade 1 or 2, 10.9%; grade 3 or 4, 0.5%; and grade 5, 2.2%). CONCLUSIONS Trastuzumab deruxtecan showed durable antitumor activity in a pretreated patient population with HER2-positive metastatic breast cancer. In addition to nausea and myelosuppression, interstitial lung disease was observed in a subgroup of patients and requires attention to pulmonary symptoms and careful monitoring. (Funded by Daiichi Sankyo and AstraZeneca; DESTINY-Breast01 ClinicalTrials.gov number, NCT03248492.) Approximately 15 to 20% of metastatic breast cancers are characterized by overexpression or amplification of human epidermal growth factor receptor 2 (HER2).1-3 The recommended first-line therapy for HER2-positive metastatic breast cancer consists of the anti-HER2 monoclonal antibodies trastuzumab and pertuzumab given with a taxane. In the CLEOPATRA (Clinical Evaluation of Pertuzumab and Trastuzumab) trial, the combination of trastuzumab, pertuzumab, and docetaxel resulted in a median duration of progression-free survival and overall survival of 18.7 months and 56.5 months, respectively.4,5 Standard second-line therapy is the antibody-drug conjugate trastuzumab emtansine, which was associated with an objective response of 43.6% (95% confidence interval [CI], 38.6 to 48.6) and a median duration of progression-free survival of 9.6 months when the drug was administered after trastuzumab and a taxane.6 No uniformly accepted standard of care has been defined after the administration of trastuzumab emtansine, and the currently available options have limited benefit, with response rates of approximately 9 to 31% and a duration of progression-free survival of approximately 3 to 6 months for third-line therapy.7-10 Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate that is composed of a humanized monoclonal antibody specifically targeting HER2, with the same amino acid sequence as trastuzumab, a cleavable tetrapeptide-based linker, and a potent topoisomerase I inhibitor as the cytotoxic drug (payload). Trastuzumab deruxtecan, which was designed to improve on the critical attributes of currently available antibody-drug conjugates, has a higher drug-to-antibody ratio than trastuzumab emtansine (approximately 8 vs. 3 to 4) while retaining a favorable pharmacokinetic profile.11 The proprietary tetrapeptide-based linker is stable in plasma and is selectively cleaved by cathepsins that are up-regulated in tumor cells.12-15 Unlike trastuzumab emtansine, trastuzumab deruxtecan has a released payload that easily crosses the cell membrane, which potentially allows for a potent cytotoxic effect on neighboring tumor cells regardless of target expression.16 In addition, the released payload has a short half-life, which is designed to minimize systemic exposure.15 In a phase 1 study of trastuzumab deruxtecan (called DS8201-A-J101; ClinicalTrials.gov number, NCT02564900), 111 patients with advanced HER2-positive breast cancer received trastuzumab deruxtecan at a dose of 5.4 mg or 6.4 mg per kilogram of body weight. The confirmed response rate was 59.5% (95% CI, 49.7 to 68.7), and the median response duration was 20.7 months on the basis of investigators’ assessment.17 Of the 43 patients with breast cancer who had a low expression of HER2 (a score of 1+ or 2+ [negative or borderline] on immunohistochemical analysis and no demonstrated amplification on in situ hybridization), 19 (44%) had a response to treatment.18 These results show promise in patients who have metastatic breast cancer with varying levels of HER2 expression, which supports the conduct of additional studies to evaluate the therapeutic potential of trastuzumab deruxtecan.17,19 We performed a phase 2 registration study of trastuzumab deruxtecan (DESTINY-Breast01) in patients with HER2-positive metastatic breast cancer who had previously been treated with trastuzumab emtansine. Methods STUDY DESIGN We conducted a two-part, open-label, single-group, multicenter study of trastuzumab deruxtecan in adults with pathologically documented HER2-positive, unresectable or metastatic breast cancer who had received previous treatment with trastuzumab emtansine. Positivity for HER2 was defined as a score of 3+ on immunohistochemical analysis or as positive results on in situ hybridization, as centrally confirmed on archival tissue. Eligible patients were adults (≥18 years of age in all country sites except for ≥20 years in Japan and South Korea) and had a performance-status score of 0 or 1 on the Eastern Cooperative Oncology Group scale (ranging from 0 [no disability] to 5 [death]). Patients were excluded if they had untreated or symptomatic brain metastases or if they had a history of noninfectious interstitial lung disease or pneumonitis resulting in the use of glucocorticoids or current or suspected interstitial lung disease or pneumonitis. (Details regarding the eligibility criteria are provided in the Supplementary Appendix, available with the full text of this article at NEJM.org.) Part 1 of the study was designed to consist of two sequential stages: pharmacokinetics and dose finding (Fig. S1 in the Supplementary Appendix). In the pharmacokinetics stage, patients were randomly assigned in a 1:1:1 ratio to receive trastuzumab deruxtecan at a dose of 5.4 mg, 6.4 mg, or 7.4 mg per kilogram administered by intravenous infusion every 3 weeks. On the basis of the pharmacokinetics analysis, two doses were identified for evaluation in the dose-finding stage, in which newly enrolled patients were randomly assigned in a 1:1 ratio. We identified the recommended dose using a predicted benefit–risk profile modeled from exposure–response, exposure–safety, and pharmacokinetic analyses as well as clinical data from this study and from the phase 1 DS8201-A-J101 study.11 In part 2 of the study, we evaluated the efficacy and safety of the recommended dose of trastuzumab deruxtecan in patients treated at the recommended dose in part 1. Part 2 consisted of two cohorts: one involved patients who had tumor progression during or after the previous administration of trastuzumab emtansine and one involved patients who had discontinued trastuzumab emtansine for reasons other than progressive disease (e.g., toxicity). Treatment continued until disease progression, the occurrence of unacceptable toxic effects, or withdrawal of consent. STUDY OVERSIGHT The study was funded by Daiichi Sankyo and AstraZeneca. The study was sponsored and designed by Daiichi Sankyo and was approved by the institutional review board at each participating site. After the collaboration was formed in March 2019, representatives from AstraZeneca were involved in study oversight and data interpretation. All the patients provided written informed consent. Data were analyzed and interpreted by the sponsor and the authors. All the authors reviewed the manuscript and vouch for the accuracy and completeness of the data and for the adherence of the study to the protocol, available at NEJM.org. Editorial assistance was financially supported by Daiichi Sankyo. END POINTS The primary end point was the overall response (complete response plus partial response) to trastuzumab deruxtecan therapy in patients who had tumor progression during or after the administration of trastuzumab emtansine and who had received the recommended dose of trastuzumab deruxtecan in both parts 1 and 2 of the study. The response was confirmed on the basis of an independent central review of imaging with the use of the modified Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1.20 Secondary end points were the response duration, progression-free survival, overall survival, response rate according to investigator assessment, best percentage change in the sum of the diameters of measurable tumors, disease-control rate (response rate plus stable-disease rate), clinical-benefit rate (disease-control rate with stable disease lasting ≥6 months), safety, and pharmacokinetics. Exploratory end points included the time until response and evaluation of exposure–response relationships for efficacy and safety. SAFETY Adverse events were categorized with the use of the Medical Dictionary for Regulatory Activities, version 20.1, and graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE), version 4.03. Potential episodes of interstitial lung disease were evaluated by an external independent adjudication committee, and grading was consistent with the NCI CTCAE. STATISTICAL ANALYSIS We calculated that a sample of approximately 230 patients would result in approximately 150 patients being treated at the recommended part 2 dose of trastuzumab deruxtecan in both parts of the study, which would provide a 95% confidence interval within 10% of the overall response rate. Enrollment was designed to continue until at least 100 patients who had received previous treatment with pertuzumab were enrolled at the recommended dose. With 150 patients, the probability that the lower boundary of the 95% confidence interval would be more than 20% was 0.982, and the probability that the estimated response rate would be 30% or more was 0.916, according to the anticipated response rate of 35%. We used the Clopper–Pearson method to calculate the two-sided 95% confidence intervals for the response rate. We used the Kaplan–Meier method to estimate the distribution of time-to-event end points of response duration, progression-free survival, and overall survival; corresponding two-sided 95% confidence intervals were calculated with the Brookmeyer and Crowley methods.21 The primary analysis was performed after all the patients who had received the recommended dose of trastuzumab deruxtecan had at least 6 months of follow-up or had discontinued their participation in the study. Results PATIENTS From October 2017 through September 2018, a total of 253 patients were enrolled and received at least one dose of trastuzumab deruxtecan at 72 sites in eight countries in North America, Asia, and Europe; 184 patients received the recommended dose of 5.4 mg per kilogram (Figure 1). The cutoff date for the data analysis was August 1, 2019. FIGURE 1 Enrollment and Study Design. The demographic and clinical characteristics of the patients who received the recommended dose of trastuzumab deruxtecan and of all the patients are summarized in Table 1 and Table S1, respectively. Among the patients who received the recommended dose, the median age was 55 years (range, 28 to 96); 23.9% of the patients were 65 years of age or older. Of the 184 patients, 97 (52.7%) had hormone receptor–positive tumors. The median number of previous lines of therapy for metastatic disease was 6 (range, 2 to 27) and included trastuzumab emtansine (100%), trastuzumab (100%), pertuzumab (65.8%), and other anti-HER2 therapies (54.3%). TABLE 1 Demographic and Clinical Characteristics of the Patients at Baseline. At the time of the data cutoff, 79 of 184 patients (42.9%) who had received the recommended dose were continuing to receive trastuzumab deruxtecan. The primary reasons for discontinuation included progressive disease according to RECIST, version 1.1 (28.8%), and adverse events (15.2%). The median treatment duration was 10.0 months (range, 0.7 to 20.5 months), and the median duration of follow-up was 11.1 months (range, 0.7 to 19.9); 128 patients (69.6%) continued to receive trastuzumab deruxtecan for more than 6 months. DOSE JUSTIFICATION In the pharmacokinetics stage in part 1 of the study, the dose of trastuzumab deruxtecan that was administered was 5.4 mg per kilogram in 22 patients, 6.4 mg per kilogram in 22 patients, and 7.4 mg per kilogram in 21 patients. The resulting pharmacokinetic profiles were analyzed in conjunction with those from the phase 1 study, DS8201-A-J10111; 5.4 mg and 6.4 mg per kilogram were chosen for the dose-finding stage. In the part 1 dose-finding stage, an additional 28 and 26 patients (who were not enrolled during the pharmacokinetic stage) received 5.4 mg and 6.4 mg per kilogram, respectively. Exposure-efficacy modeling showed a significant relationship between exposure and response rate and a trend for longer progression-free survival at higher doses. Similarly, exposure–safety modeling showed a significant relationship between exposure and key adverse events, including interstitial lung disease. On the basis of the balance of safety and efficacy, a dose of 5.4 mg per kilogram was recommended.17,23 EFFICACY Among the 184 patients who received trastuzumab deruxtecan at the recommended dose of 5.4 mg per kilogram, the confirmed response rate on independent central review was 60.9% (95% CI, 53.4 to 68.0); of these patients, 6.0% had a complete response, and 54.9% had a partial response. Another 3 patients (1.6%) had progressive disease, and 2 (1.1%) could not be evaluated. Most of the patients for whom both baseline and postbaseline data were available had a reduction in tumor size (Figure 2A). The disease-control rate was 97.3% (95% CI, 93.8 to 99.1), and the clinical-benefit rate was 76.1% (95% CI, 69.3 to 82.1). The median time until response was 1.6 months (95% CI, 1.4 to 2.6), an interval that corresponded to the time until the first imaging after baseline. Among the 180 patients who had tumor progression during or after the administration of trastuzumab emtansine, the confirmed response was 61.1% (95% CI, 53.6 to 68.3). FIGURE 2 Response to Trastuzumab Deruxtecan, According to Tumor Size and Subgroup Analyses. Prespecified subgroup analyses showed consistent responses across demographic and prognostic subgroups, including previous receipt of pertuzumab (78 of 121 patients [64%]), hormone-receptor status (positive status, 56 of 97 patients [58%]; negative status, 55 of 83 patients [66%]), and receipt of trastuzumab deruxtecan immediately after initial trastuzumab emtansine therapy (36 of 56 patients [64%]) (Figure 2B). The efficacy results for doses other than 5.4 mg per kilogram are provided in Table S2. The median response duration was 14.8 months (95% CI, 13.8 to 16.9) (Figure 3A). The median duration of progression-free survival was 16.4 months (95% CI, 12.7 to not reached) among all patients and 18.1 months (95% CI, 6.7 to 18.1) among the 24 patients who were enrolled with treated and asymptomatic brain metastases. Estimated overall survival was 93.9% (95% CI, 89.3 to 96.6) at 6 months and 86.2% (95% CI, 79.8 to 90.7) at 12 months; the median overall survival was not reached at the time of this report (Fig. S2). FIGURE 3 Kaplan–Meier Analysis of Response Duration and Progression-free Survival. SAFETY Of the 184 patients who received the recommended dose of trastuzumab deruxtecan, 99.5% had at least one adverse event during treatment; of these patients, 57.1% had an adverse event of grade 3 or higher (Table S3). The most common adverse events of grade 3 or higher that occurred in more than 5% of the patients were a decreased neutrophil count (in 20.7%), anemia (in 8.7%), nausea (in 7.6%), a decreased white-cell count (in 6.5%), a decreased lymphocyte count (in 6.5%), and fatigue (in 6.0%) (Table 2); 3 patients (1.6%) had febrile neutropenia. (Table S4 provides a list of all the adverse events that were reported in at least 10% of the enrolled patients.) TABLE 2 Adverse Events in the Overall Population of 184 Patients. Adverse events led to a dose interruption in 65 patients (35.3%) and to a dose reduction in 43 patients (23.4%); 28 patients (15.2%) discontinued treatment because of an adverse event. Adverse events that led to discontinuation in at least 2 patients included pneumonitis (in 11 patients) and interstitial lung disease (in 5 patients). A total of 25 deaths were reported, including 7 that occurred during treatment as a result of either disease progression (in 3 patients) or adverse events (hemorrhagic shock, general physical health deterioration, pneumonia, and acute organ failure in 1 patient each). During survival follow-up (which was defined as 47 days after the end of treatment), 18 of the 25 deaths occurred, 2 of which were caused by events associated with interstitial lung disease that started during treatment and are among those described below; the remaining 16 deaths were considered by investigators to be unrelated to trastuzumab deruxtecan. Eleven patients (6.0%), including 1 who could not be evaluated at baseline, tested positive for antidrug antibodies; only 3 patients had positive results for such antibodies after the baseline assessment, and all 3 cases resolved during treatment. A decrease in the left ventricular ejection fraction occurred in 3 patients (2 with grade 2 and 1 with grade 3); all the patients were asymptomatic and had recovered or were recovering after an interruption in the study treatment. No events of cardiac failure associated with the decrease in the ejection fraction were reported. No patients had an ejection fraction of less than 40% or a decrease from baseline of 20% or more, and no patients discontinued treatment because of a decrease in the ejection fraction. Overall, 25 patients (13.6%) had interstitial lung disease related to the receipt of trastuzumab deruxtecan, as determined by an independent adjudication committee. These events were primarily NCI CTCAE grade 1 or 2 (10.9%); 1 patient (0.5%) had a grade 3 event, and no patients had a grade 4 event. Four deaths (2.2% of the patients) were attributed to interstitial lung disease by independent adjudication and were initially reported as respiratory failure, acute respiratory failure, lymphangitis, and pneumonitis in 1 patient each by the treating investigators; the primary cause of death was reported as disease progression (in 2 patients) and adverse events during survival follow-up (in 2 patients). Among the investigator-reported cases of interstitial lung disease of any grade, the median time until the onset of lung disease was 193 days (range, 42 to 535). At the time of the data cutoff, 7 patients with interstitial lung disease had recovered, 2 were recovering, 10 had ongoing interstitial lung disease, and 4 had died; status was unknown for 2 patients. Among the patients with investigator-reported interstitial lung disease, the median duration from the date of onset to the date of recovery was 34 days (range, 3 to 179). Of the 20 patients who were reported to have interstitial lung disease of grade 2 or higher, 13 received glucocorticoids and 7 were hospitalized. Discussion In this phase 2 study, trastuzumab deruxtecan (at a dose of 5.4 mg per kilogram) had durable antitumor activity in patients with HER2-positive metastatic breast cancer who had undergone extensive previous treatment, with a confirmed overall response rate of 60.9%, a median duration of progression-free survival of 16.4 months, and a median response duration of 14.8 months. Efficacy results were consistent across key subgroups, including patients who had received previous pertuzumab therapy. These results validate earlier observations from a phase 1 study (DS8201-A-J101), which showed a response of 59.5% (95% CI, 49.7 to 68.7) in a similar patient population.17 The response rate and overall efficacy observed with trastuzumab deruxtecan in this study appear to substantially exceed those of currently available HER2-directed regimens and new agents in development, although cross-trial comparisons must be interpreted with caution. In two recent phase 3 trials, the combinations of margetuximab (another anti-HER2 antibody) plus chemotherapy (SOPHIA)9 and neratinib plus chemotherapy (NALA)10 were compared with standard-of-care therapy, with response rates ranging from 16 to 32.8% in both the experimental group and the control group in the two trials. In the SOPHIA trial, the median duration of progression-free survival was 5.8 months in the experimental group and 4.9 months in the comparator group; in the NALA trial, the estimated percentage of patients with 6-month progression-free survival was 47%. Previously, investigators in the TH3RESA trial,7 which compared trastuzumab emtansine with a treatment of the physician’s choice after two previous anti-HER2 regimens, found a response rate of 31% in the trastuzumab emtansine group and 9% in the comparator group (median progression-free survival, 6.2 months vs. 3.3 months). In the EMILIA trial6 evaluating trastuzumab emtansine as a second-line therapy in patients who had previously received trastuzumab plus a taxane, the overall response was 43.6% (95% CI, 38.6 to 48.6), with a median duration of progression-free survival of 9.6 months. Although the process is not fully understood, resistance to trastuzumab emtansine may develop through inadequate binding of the antibody to the HER2 receptor owing to down-regulation or loss of HER2 expression, heterogeneous HER2 expression (either intratumoral or from lesion to lesion), receptor mutation, or expression of a different HER2 isoform.24,25 Alterations in lysosomal trafficking and degradation also have been implicated in resistance to trastuzumab emtansine.26,27 Alternatively, cancer cells may develop resistance to the emtansine payload. In our study, trastuzumab deruxtecan retained efficacy in patients who had previously been treated with trastuzumab emtansine, a finding that may be attributable to the distinct pharmaceutical properties of trastuzumab deruxtecan, such as the potent topoisomerase I inhibitor payload instead of a microtubule inhibitor, an increased drug-to-antibody ratio (approximately 8 with trastuzumab deruxtecan vs. approximately 3.5 with trastuzumab emtansine), and the high membrane permeability of the released payload, which can result in a bystander antitumor effect.28 The reported efficacy could also be due to the use of a higher dose of trastuzumab deruxtecan (5.4 mg per kilogram) than the dose of trastuzumab emtansine (3.6 mg per kilogram). Moreover, trastuzumab deruxtecan has shown activity in patients with metastatic breast cancer with low HER2 expression (i.e., a score of <3+ on immunohistochemical analysis and negative results on in situ hybridization).18 When considered in the context of heterogeneous HER2 levels, this finding may account for activity in patients with disease that is resistant to trastuzumab emtansine. In our study, gastrointestinal and hematologic toxic effects were the most common adverse events. Other HER2-targeted therapies, such as trastuzumab and pertuzumab, have been associated with a risk of cardiomyopathy, particularly left ventricular dysfunction.29-32 In contrast, clinically significant cardiotoxicity was not observed here or in the DS8201-A-J101 study.17,33 Trastuzumab deruxtecan was associated with a substantial risk of interstitial lung disease (13.6%), which led to death in some patients. Other HER2-directed therapies, including trastuzumab and trastuzumab emtansine, and topoisomerase I inhibitors have been associated with pulmonary toxicity.30,34,35 In accordance with the study protocol, investigators managed interstitial lung disease with dose reductions or discontinuations, the administration of glucocorticoids, and supportive care. (Details regarding recommendations for management are provided in the Supplementary Appendix.) Education and close monitoring for signs and symptoms of interstitial lung disease (including fever, cough, or dyspnea) is recommended for early detection. If interstitial lung disease is suspected, evaluations should include high-resolution computed tomography, consultation with a pulmonologist, and testing of pulmonary function and oxygen saturation, and other tests could be considered, as needed (Table S6). Although data on treatment for interstitial lung disease associated with trastuzumab deruxtecan are limited, interruption of the drug regimen and prompt intervention with glucocorticoids when appropriate may help reduce the severity of this complication.17,36 However, more research is needed to determine who is at greatest risk for interstitial lung disease and the most effective method for mitigating this toxic effect. DESTINY-Breast01 was a single-group study with a median follow-up of only 11 months. Yet, it provides validation of the earlier phase 1 results, and randomized trials are under way (NCT03523585 and NCT03529110) to confirm these findings as well as a direct comparison with trastuzumab emtansine for the treatment of patients with HER2-positive metastatic breast cancer. Trastuzumab deruxtecan is also being evaluated for the treatment of metastatic breast cancer in patients with low HER2 expression (NCT03734029) and has shown early activity with a response rate of 44.2% in a patient population for which currently available HER2-directed therapies are ineffective.18 In this global, phase 2 study, trastuzumab deruxtecan had a high level of clinical activity in patients with HER2-positive metastatic breast cancer who had undergone extensive previous therapies. Such therapy was associated with a substantial risk of interstitial lung disease, a toxic effect that requires attention to pulmonary symptoms and careful monitoring. NOTES This article was published on December 11, 2019, at NEJM.org. A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. Supported by Daiichi Sankyo and AstraZeneca. Disclosure forms provided by the authors are available with the full text of this article at NEJM.org. SUPPLEMENTARY MATERIAL Protocol (nejmoa1914510_protocol.pdf) DOWNLOAD 8.62 MB Supplementary Appendix (nejmoa1914510_appendix.pdf) DOWNLOAD 393.28 KB Disclosure Forms (nejmoa1914510_disclosures.pdf) DOWNLOAD 563.25 KB Data Sharing Statement (nejmoa1914510_data-sharing.pdf) DOWNLOAD 68.45 KB REFERENCES 1. Gonzalez-Angulo AM, Litton JK, Broglio KR, et al. High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smaller. J Clin Oncol 2009;27:5700-5706. Go to Citation Crossref PubMed Web of Science Google Scholar 2. Onitilo AA, Engel JM, Greenlee RT, Mukesh BN. Breast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival. Clin Med Res 2009;7:4-13. Go to Citation Crossref PubMed Google Scholar 3. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-182. Go to Citation Crossref PubMed Web of Science Google Scholar 4. Swain SM, Baselga J, Kim S-B, et al. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med 2015;372:724-734. Go to Citation Crossref PubMed Web of Science Google Scholar 5. Swain SM, Miles D, Kim S-B, et al. End-of-study analysis from the phase III, randomized, double-blind, placebo (Pla)-controlled CLEOPATRA study of first-line (1L) pertuzumab (P), trastuzumab (H), and docetaxel (D) in patients (pts) with HER2-positive metastatic breast cancer (MBC). J Clin Oncol 2019;15:Suppl:1020-1020. abstract. Go to Citation Crossref Web of Science Google Scholar RELATED ARTICLES ORIGINAL ARTICLEDEC 11, 2019 Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer R.K. 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