Should I take Kisqali for early-stage breast cancer?

I totally understand. I don’t want to be the rat in the lab either. Sometimes I feel we are on a conveyor belt just going thru the steps of what they are experimenting with. Taking 3 drugs sounds excessive to me for your cancer stage. But I’m not a doctor and can’t judge for sure. I’m doing 19 radiation treatments now and then to take Letrozole for 5 years. That’s it.

I let them know that I am not interested in this trial. I want to know what other options are. I’m not filling the quota of trial study candidates.

Were you stage 1 grade 1?

Anatomical stage 2a Pathological 1b Grade 3

Stephanie, I have similar stage and grade. I am also 1B. You are much younger than me. (62) My doctor would have recommended Kisquali only if I didn’t do chemotherapy. I believe because of your age and if you are premenopausal then Lupron is used for hormone suppression.

My treatment plan is going to be zoladex and letrozole. I had a double mastectomy with side clear margins and no lymph node involvement.

I am post menopausal- I’m guessing you are pre menopausal. That would make sense.

I am premenopausal

My doctor recommended the same regimen and I am 38yr old

I am stage 2a. I had chemo, surgery, radiation. I was recommended letrozole and kisqali. I am 68, onco score 17. I am going to refuse kisqali for the reasons mentioned. 3 years of those side effects plus effects of letrozole, they say for 10 years. I'm just not going to spend these years dealing with debilitating side effects and related health issues. I can't do it to myself. I will try the letrozole, that seems bad enough.

I see that you are 40; good. Lupron causes dementia in older adults; fact.

This is such a personal decision that deserves careful consideration, and it sounds like you're doing exactly that by weighing the benefits against potential side effects. Many people in this community face similar decisions about newer treatments, especially when the benefit margins feel small compared to quality of life concerns. Getting a second opinion from another oncologist might help provide additional perspective on whether this regimen is truly necessary for your specific situation. Whatever you decide, trust your instincts about what feels right for your body and your life - you know yourself best.