Does Turmeric Affect Anastrozole's Effectiveness?

I had the same question. Was told (by my doctor) that it was fine to take both.

Thank you! My oncologist also told me it was OK but I researched it and found out that circumin that is in tumeric has estrogen properties. Checked MSK supp info, but not listed. Not recommended if you’re taking tamoxifen, however. 

Hi! My oncologist told me not to take turmeric because of the estrogen like properties. I am on letrozole, which is similar to anastrozole and is an aromatase inhibitor.

Overview Learn more … Yes, turmeric and its active compound curcumin can affect estrogen. In large amounts, turmeric may reduce the effects of estrogen, especially when taken with estrogen pills. A 2013 study also found that curcumin may lower estrogen levels in cells outside the body, but it's unclear if it has the same effect in humans. In vitro and in vivo studies suggest that curcumin may inhibit estrogen signaling pathways, which could explain its antitumor properties. Susan G. Komen Turmeric - Susan G. Komen® Large amounts of turmeric might interfere with the effects of estrogen. Taking turmeric along with estrogen might decrease the effects of estrogens. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. Glyburide (Diabeta, others). Interaction Rating=Minor Be ... I found this on turmeric. Interesting

Laura, I hope you get this message. I’m 63, and got diagnosed with stage 1 ER+ cancer in my left breast. I had a lumpectomy and radiation. I’m supposed to start Anastrozole 2 weeks ago but have been putting it off. I wonder if I really need it? My onco score is 24. Probably not low enough to think about skipping meds. Do you have some advice on Anastrozole? Or if it’s worth taking, or something better? Thank you, my name is Melody

Hi Melody, I have been on Anastrozole since 3/13/24. I have had very few side effects. Hot flashes which have been tolerable, hair thinning recently started,a little fatigue. I was having sleep issues, but the fatigue seems to help. Everyone is different, but I would try it. There are other AIs if you have problems. My best to you. Janet the Unicorn

This is such an important question to bring up with your healthcare team, especially since you're managing both arthritis and breast cancer treatment. Drug interactions can be complex, and your oncologist and pharmacist are the best people to review your specific medications and supplements together. Many patients find it helpful to bring a complete list of everything they're taking to their appointments. The community here has great experience navigating these kinds of treatment questions - have others found helpful ways to discuss supplement interactions with their care teams?