Has anyone had trastuzumab subcutaneous injections for HER2+ breast cancer?

It sounds like you're navigating a lot with this new diagnosis and treatment plan. Many community members have shared experiences with trastuzumab subcutaneous injections, and it's encouraging that your medical team is taking care to monitor your heart function before starting treatment. The subcutaneous form can be much easier for patients who have vein access challenges, and rotating injection sites helps minimize any discomfort. Hopefully others who have been through similar treatment will share their experiences to help you feel more prepared and supported during this journey.

Hi Mary. I started my treatment with the Trastuzumab injections but had to discontinue them because of excessive diarrhea. I then went with intravenous drip through my port and had no problems. I’m praying that you will have no problems with the injections. If you do, there are other options.

Kimberly in Thank you for responding , never heard about subcutaneous injection until my oncologist and I were discussing other options because i had to have my original port from battle with cancer removed because i hadn't used in 14 months and it was starting to cause some numbness in in arm and fingers , but in October they found a little spot and already took it out and what shocked me they said it's HERS Positive this time, might have to have another port put in because looks like my Insurance is Not going to approve for subcutaneous injections.

Mary W., at first I did not want a port but after going through chemo and immunotherapy and labs, I’m glad I got one put in. You will have a lot more options with a port. Keep me posted on how you are doing. You got this!!! 🙏

Thank you Kimberly and I have already talked to to my Breast surgeon about putting in another in port.🩷

I dont know how this happened When I saw my medical oncologist In October after having 1.4 mm tumor removed for HERS positive cancer by my surgeon and this time with all margins clear and all tissue she removed around was benign. I was previous treated for TNBC In 2023 and chemo with carobplation aand Paclitaxel every three weeks with Keyturda surgeon was successful with NED afterward,but the Keytruda caused me to have adrenal Insufficiency and neuropathy really bad in toes and feet and some Lung Problems,have to be hydrocortisone for the rest of my life abd taking Lyrica for neuropathy still in feet.I said I would never have Immunotherapy again .I discuss this with my medical oncologist this time i would try the monoclonal antibody therapy Herceptin if i could maybe get the subcutaneous injection and I Will be doing Radiation .I thought we all set until I got a letter from My Insurance company saying they have approve Trazimera and it is a immunotherapy drug ,No way will I have Immunotherapy chemo again ,I still Remember Today how close to death I felt like before they found at another hospital i had all of these things going on.I will do radiation but until my medical oncologist and I try to figure out while i was even prescribed a immunotherapy drug Again.I am an advocate for myself and i do a lot of Google search about HERS positive Cancer.I just don't understand .Please have anyone else had this happen to them .Might need to get second opinion now from another medical oncologist.

What’s TNBC

Triple Negative Breast Cancer.

Has anyone on the forum developed esphogostis while getting chemo and radiation and how long did it take to resolve my sister is in hospital and i am very concerned about her.

I have HER2 positivity, as did my aunt who was part of the study many years ago for drugs like the one they want to give you. I am currently getting a similar drug through my port and I'm experiencing very few side effects.

Mary W, the neuropathy you’re unfortunately experiencing is most likely due to the chemotherapies you were given. Paclitaxel is notorious for causing it; up to 85% of patients given paclitaxel get neuropathy. Carboplatin is considered less neurotoxic than cisplatin, but neuropathy incidence remains substantial with the combination of carboplatin and paclitaxel.

I did both Paclitaxel and Carboplatin on my first Chemo treatment in 2023. I also have adrenal Insufficiency and they definitely seem to think that it was from Keytruda .