Has anyone taken BRAF/MEK inhibitors with immunotherapy like Opdualag?

Treatment combinations can feel overwhelming when exploring new options. Many patients in this community have experience with various BRAF/MEK inhibitors and immunotherapy combinations, and connecting with others who have walked similar paths can provide valuable insights alongside your medical team's guidance. Hoping community members will share their experiences to help you feel more informed as you consider this treatment approach.

I am Braf neg so inhibitors don’t work for me. I was on Opdivo first which my melanoma came back 8 mos after tx. It gave me a horrible rash. Then I went on Kaytruda and Yeryoy for 4 cycles and gave me Addison’s disease and autoimmune hepatitis. I moved from Las Vegas to my daughter in Spokane, WA. I had a virtual consultation with a melanoma specialist at Fred Hutch Cancer Center in Seattle. He suggested I try Opdaulag. The 20 lung lesions I had are gone. Right now I’m waiting for a brain MRI to see what the indeterminate findings in my brain are 🙏🍀.

I get my first treatment of Opdualag March 17. Did you have any side effects? I have been very fortunate with the Opdivo, other than itchy skin and minor rashes. I will be thinking and praying your MRI results come back good!! Thank you for your reply.

I have no side effects and feel great. Thks for your good wishes and keep me posted how you are doing on Opdulage

Thank you for your response and hope your MRI results come back with good news.