Why do I have leg pain at night on Orgovyx and Nubeqa?
Community Member
7 days agoI have been taking Orgovyx and Nubeqa for almost 2 years after PSA rose from .7 to 1.9. PET scan showed lymph node involvement in pelvis, abdomen and neck, small spots but there nonetheless. PSA now <.01 so undetectable. For the last six months I have experiencing a dull ache uncomfortable feeling in legs at night that sometimes interferes with my sleep. Has anyone else experienced this? I welcome any insight our community can provide.
Accepted Answer
Night-time leg discomfort can be a concerning side effect that affects sleep quality during treatment. Many patients on hormone therapy medications report similar experiences, and bringing this up with your medical team would be valuable since they can assess whether this might be related to your current treatment plan or suggest ways to help manage the discomfort for better rest.
3+ patients found this helpful
Community Member
7 days agoNight-time leg discomfort can be a concerning side effect that affects sleep quality during treatment. Many patients on hormone therapy medications report similar experiences, and bringing this up with your medical team would be valuable since they can assess whether this might be related to your current treatment plan or suggest ways to help manage the discomfort for better rest.
Community Member
7 days agoIf you are not already, go for walks every day. Also increase protein intake, and take calcium supplements with vitamin D. Make sure they are keeping track of your calcium levels, you might be leeching calcium from your bones.
Community Member
7 days agoWalking and gym workouts 3x each week. Protein shakes and taking supplements every day. Regardless I will have doctors check calcium levels at my appointment later this month. Thanks for your input.
Community Member
a day agoHow do pluvicto work?
New to the community?
Create an account to connect with others navigating cancer.
Related Questions
- How do others cope with fatigue and depression during prostate cancer treatment?
- How can I manage brain fog and insomnia on prostate cancer treatment?
- How did others handle ADT side effects during radiation for Stage 3a prostate cancer?
- How do others handle weakness from Provicto for prostate cancer?
- Is PSA rising from 0.05 to 0.07 after prostate surgery cause for concern?
- What to expect during ERBT and Orgovyx after prostate cancer recurrence?
- How does catheterization work after surgery?
- Why do I have leg pain at night on Orgovyx and Nubeqa?
© 2026 Outcomes4Me Inc. All rights reserved.