Is Anyone Taking Enhertu?

It will be my next med. how are you dealing with it?

Yes. I have been for 2.5 years. I have HR positive HER2 negative stage four breast cancer with a PALB2 mutation. The biggest side effect is being tired more than I like. I get a regular heart scan along with the normal CT and bone scan.

Hi Pat, Enhertu hit me hard. I just had my first one last Wednesday. I am sleeping a lot and waking up tired. I am HR positive and HER2 1+(low) with PALB2 and RAD51B as a variance of unknown significance. I was previously on: - ribociciclib/fulvestrant/Xgeva/Zoladex (Jan 2024-Jan 2025) -paclitaxel, trastuzumab and pertzumab (January 2025-March 2025) I was first diagnosed in 2020 with stage 3, Triple positive and had dose-dense chemo (AC and paclitaxel). Did DMX, radiation and Trastuzumab. It metastasized to my spine and hips Dec 2023, liver in Sept 2024, more spots showed up in my spine and liver in Jan 2025 scans, so did radiation in my spine. They will be doing a CT, bone scan and MUGA in June to see if the Enhertu is working. How have you been dealing with the tiredness? Has it minimized? Are you able to work?

I was diagnosed with stage 4 in April 2022. It is “just” in my bones so far. I was Initially treated with ibrance and Fulvestrant but there was progression so switched to Enhertu. One of the pre-meds was dexamethazone, a steroid, which gave me energy for a few days. I had to stop it after about a year since it was too hard on my stomach. I did end up retiring about 9 months after I started Enhertu as my stamina and memory were not keeping up. I do the infusion on Thursday and try not to schedule anything for 4 days. Ask your doctor about a steroid premedication. It helps with the nausea as well.

I had my first infusion of that one last Friday. I’m really tired and nauseous most days.

Not yet, but I know people who are & if my current, 2nd line, doesn’t work, I will be moving on to Enhertu.

I’ve been on it over two years; I have the usual side effects.

I have been on Enhertu since July 2024. I haven't had any side effects. I was told my hair may come out again by the pharmacist, but this time, it did not. I have an infusion every 21 days, and I feel great after each session. Of course, everyone is different. Hang in there.🩷🩷

I just started last week!

I just started yesterday. Today tired and what seems like a sinus headache? Previously on Kisqali and Letrozole since diagnosed 8-24-24. Have had lymphedema in my arm since diagnosis which was Inflammatory BC. Am HERS2 1+(low) and HR positive.

Many people in this community have experience with Enhertu and would likely be happy to share their insights about this treatment. Consider sharing a bit more about what specific aspects you'd like to know about - whether it's side effects, how long others have been on it, or general experiences - as this can help community members provide more targeted support and information that might be most helpful for your situation.