What treatments are used for AKT mutation in stage 4 breast cancer?

Hello Tanya and welcome I to have been diagnosed with mbc stage 4 in the spine and hip but no new test have been done except a new bone scan and 10 rounds of radiation therapy how is your pain and recovery going

Tanya, welcome to the club no one wants to be a member of. Sorry you are going through this, and I’m not familiar with that mutation because I don’t have my report in front of me, but I wanted to share that that test picks up e-v-e-r-y little thing and is such a useful tool. I was dx 4MBC with liver Mets 3yrs ago.Also in bones:ribs, spine, hips, skull. I get the Guardant 360 2x a year and each time it picks up additional “mutations of unknown significance” with percentages. On the report, it identifies these variants and what clinical trials (if any) are in the works. I was on ibrance/fluvestran/xgeva for the 1st 18 mos and then switched up to lynparza/xgeva when my numbers crept up again. Since swapping treatment I’m very pleased to report liver lesions have resolved (!) and the bone stuff is stable. This may change with time, but for now am happy. And I just got my latest guardant 360 report with several tumor burdens of unknowns listed(each time it’s run, they seem to find another). My understanding of this is that my cocktail is working, and as the cancer mutates and tries to invade my endocrine therapy kicks its ass. So am hoping this info may help you as you evaluate options with your team. Your Onc will explain this and more as you review your results together. Hope this helps, and wishing you health.

Hi Tanya I'm sorry to hear this. I was dx Dec 2023 spine, hips and liver. I'm from Canada. I feel that the U.S. is very fortunate as they have more resources. I recently ordered a Tempus xT kit from the U.S. to test for gene alterations. Im currently on ribociciclib/fulvestrant/Zoladex/Xgeva. Hoping to get a more targeted treatment once I receive Tempus results. This club sucks but it has the best members. Some of the kindest people I've met are from this club

Tanya, I call myself a metavivor. My 9th yr anniversary is 1/19. Overall, I've felt pretty good. I just have bone Mets in every bone except below my elbows and knees. With all the new meds I'm sure you will be very well for a long time. There will be challenges, but you will deal with them and look forward to better days. Prayers for you 🙏❤️

AKT mutations in metastatic breast cancer can be challenging, and it's completely understandable to seek information about treatment options from others who may have similar experiences. While treatment approaches can vary based on many individual factors that oncologists consider, some patients with AKT mutations may be candidates for targeted therapies or clinical trials specifically designed for this mutation. Connecting with others in this community who have navigated similar diagnoses could provide valuable insights and support during this time.