Has anyone experienced low white blood cell count with KISQALI?

Hi.. I am new to MBC diagnosis and treatment but some questions that come to mind are: has ur mets sites remained stable? If u have any bone mets are you on anything specific for that? Has ur tumor biology changed? As there may be specific meds for that. There is really good recent talk by Dana Farber on YouTube that I will post here and it goes over various lines of therapy. Like you I thought chemo comes later.

https://youtu.be/9lWpFoF7Lu8?si=hyrvkcAbNWga9joW

And another general talk about overview of treatments https://youtu.be/MB2pGWuyjUg?si=HxjEkZf6ftO8js7_

Thank you! I really appreciate it.

I was diagnosed with stage four metastatic breast cancer that had spread to my lungs and some lymph nodes in my right armpit. The cancer was in my right breast. I did not get a mastectomy. I started chemotherapy on September 16th and had my last chemo treatment on December 23rd. Every Friday I had my treatments and every three weeks I received Herceptin and Perjeta. On New Year Eve I was told I was in remission and that I was done with chemotherapy. I will have immunotherapy treatments every three weeks for the rest of my life. Herceptin and Perjeta. I have been in remission now for 2 years.

Congratulations and I’m so excited to hear about your remission. It gives me hope. Was your cancer administered via IV. What exactly is Herceptin and Perjeta. Are they pills, shots or infusions?

My white cell count dropped drastically after just 2 1/2 weeks on Kisqali . I became so sick I had to go in the hospital. My doctor discontinued the Kisqali .Now I'm taking letrozole and my tumors are shrinking I'm having very good results!

I have MBC ER+ for almost 9 years. I've been on Kisqali for 1.5 years. I had severe disease in Sept and we reduced the dose. Now I have inflammation in my lungs. I had a successful 7.5 years with Ibrance. Started with Ibrance and letrezole; then, Ibrance and fluvestrant. Now, Kisqali and exemestane. I'm currently just taking exemestane. You are your best advocate. Ask more questions, use this app to learn the NCCN Guidelines for your diagnosis to write down your questions. I leave space between questions, so I can write down their answers. You can do this! If you don't like the answers find another oncologist. I had an oncologist ask me my pain level "2". She prescribed oxycodone, because I was going to need it. I don't! She is no longer my oncologist. I take 90mg Cynbalta daily. It helps bone pain and depression. Also, take someone with you to your next appointment. Keep you on task, maybe write down the answers. Prays coming..

I’m about even with you. I’m on xeloda for a while. If I’m starting to feel really bad they give me an extra week off. I don’t want to go liquid chemo.

I've had alot more side effects from Kisqali than Ibrance.

Virginia knowing your taking Cymbalta which is a SSRI I took it for 7 years but for mntal health today I take effexor which helped me I never had hot flashes. But what I was going to say Cymbalta is a great SSRI but the w/d's are for me the worst drug I've had to get off of please don't just stop taking it the dr has to help you safely get off. I take pain meds but for reasons that have nothing to do with cancer. When I have the money I'm going back for my medical mmj card RSO takes so many side effects away and there is no w/d's.

https://marijuanadoctor.com/blog/rick-simpson-oil-what-it-what-rso-used

You need a new doctor

I was dx with stage 4 this past June and in July started on 400 MG Kisqali + Letrozole. My neutrophils dropped like a stone over a couple of cycles to a low point of 1.2 or maybe even 1.1. But this is a common side effect of Kisqali. My dosage and timing were not reduced because I never fell below the magic number of 1.0. Since then over the past few cycles my neutrophils have gone up, most recently to 1.7. I'm going to ask if I can be increased to 600mg. But I'm happy to say that even at 400 MG the Kisqali seems to be working well, and I don't have any side effects whatsoever

I’ve been on Kisqali 600 mg and Femara since Aug. 2023, and my wbc has been low from the beginning. My last labs showed them at 23, and neither of my oncologists (Memphis and MD Anderson) have been concerned with that number to lower my dose, which I’m perfectly fine with! They’re just watching my numbers and telling me to be cautious in public places. Do you know what your wbc is?

Hi Leigh, my wbc have also been lower than normal range but my doctor says only cares about neutrophils... I have a dental appt next wk and due to low wbc I have been given antibiotics to take prior to appt.

Hello Deanna, kisqali was my first round of treatment back in October when I started cause I have MBC stage 4 spread to my lung and some of my lymph nodes. I had to go off of it in December because of my liver enzymes being too high. It’s taken five weeks for my liver to return to normal . I’m starting on Ibrance tomorrow.

I've been on Kisqali for about 3 months now and I haven't really had any bad side effects other than joint pain but I take MSM daily and it really helps

Neutropenia (low white blood cell count) is a common side effect that many patients experience with KISQALI, and dose reductions or treatment breaks are standard approaches doctors use to manage this. It sounds like you've been working closely with your care team to find the right balance, and many community members here have navigated similar decisions about treatment adjustments - hopefully others will share their experiences to help you feel less alone in this journey.