Nausea and Vomiting with Kisquali for Breast Cancer?

I, too , are Stage 4 to some bones. I have been on Kisquali since June 2024 and Letrozole. At first, I was very scared to take because of all the side effects noted. But it turned out fairly good. I do have hot flashes, but I started having hot flashes when I started tamoxifen when I was 48, and I am now 65. The hot flashes are more extreme, but I deal with them. Other than that, I feel good. I hope it stays that way. Keep in touch and let me know how you are doing.

AnnaMarie, I have been on Kisqali & exemestane for about a year. The exemestane makes me nauseated if I don't eat before taking it. I take ondansetron, if I get nauseous. I works well for me.

I’m on Kisqali since May 2023. Started at the 600 dose, but was put on 400 due to some bloodwork being too low most of the time. Maybe an occasional hot flash other than that nothing

Yes. I take anti nausea meds and try to eat with/before taking meds. Sometimes it helps.

I take my kisqali as I’m getting into bed. I’ve been on it for just about 2 months ( 3 weeks on/1 week off) and haven’t had any nausea.

I have also and I can’t drink coffee or tea anymore, up they come. I take a nausea pill (Ondansetron) about a hour before I take Kisqali and taking Kisqali at night helps me manage the side effects, I sleep through them. Best wishes 💕

Very interesting to hear about other people's experience with Kisqali. I have been taking Kisqali since July 2024 when it was discovered that my bone mets (originally found in April 2024 in my spine, hip, a few vertebrae, upper leg and skull) were spreading to other bones and several spots of the cancer were showing up in my liver. Original BC diagnosis was Spring 2022. First treatment was double mastectomy and 15 sessions of radiation followed by letrozole daily and Zometa infusions every 6 months. Thought I was totally cancer free but not so! With the spread of bone mets I was taken off letrozole in July and started Kisqali at 600 mg but my blood counts were concerning so the dosage has been reduced to 400 mg. Feeling ok, no nausea or hot flashes. Just tired with no energy or stamina. Also taking monthly injections of fulvestrant and the Zometa infusions have been increased now to every 3 months. Still being closely monitored to get the right balance of meds. I'm in Toronto, Canada.

I had a little nausea and vomiting but not to bad got worse when switched to verzenio and worse when put on oral chemo 1,000mg of Capecitabine 2 weeks on 1 week off

Youre in my prayers Deanna! God Bless***

Many members of this community have shared experiences with digestive side effects from various treatments, and connecting with others who understand can be really valuable. It's worth discussing these symptoms with your healthcare team, as they may have strategies to help manage them and ensure you're getting the most benefit from your treatment.