Does a Significant PSA Reduction Change Cancer Stage?

It does not reduce the cancer stage. Stage relates to the location/spread of the cancer.

Hey Dionicio, not sure but I think the stages downgrade based on current status. Great question for our respective Oncology teams.

My PSA in February this year was 4.8 now in July it is 216 do I have a fighting chance your is only 20 but the doctors supposed to do something when it is over 4 they failed me I pray you get better my brother

It really depends I have metastatic in 2 lymph nodes as of 4 years ago On Xytiga and prednisone daily and a shot of Lupren every 4 months I do my bloodwork monthly My PSA is less than 0 and testosterone is less than .20 but I’m still stage 4 if I stopped the meds both will raise technically I am responding to treatment Good luck on your journey

Barry, if it provides hope, I was diagnosed 6 1/2 years ago. Did 3 years Lupron concurrent with 2 years Xytiga with prednisone and 45 days of IMRT for 81 Gys. I’m at year 6.5. PSA remains at <.1. Testosterone sank to 15 and 8/6 was 60. I do labs every three months. I’m feeling well and uber grateful at age 77. Be well, Barry :)

I start talking medicine this week but in afraid do that sounds crazy I still got my mind once you take the medicine and chemotherapy that when you get sick

What medic, Roy?

Thank you TD My journey started 6 years ago and maybe have 3-4 years to go so I’m hanging longer than the average Feel great at 72 and I never wanted to be one of those really old guys with a cane walking down the street no one notices When it hits my bones I’ll take care of the situation my self. All good 👍

That's a great question about how PSA changes relate to cancer staging. While a significant drop in PSA levels can be an encouraging sign that treatment is working, cancer staging is typically determined by factors like tumor size, location, and spread rather than PSA levels alone. This is definitely something to discuss with your oncology team, as they can explain how your specific test results and imaging studies factor into your overall treatment picture and what the PSA reduction means for your care plan.

I've been told that you never go back from Stage IV prostate cancer. My PSA has been 0 for over 2 years and the latest PET and MRI showed no indication of cancer. So am I cured? The oncologist said, "If I didn't know better I'd say you are cancer free. But I know better. Your cancer is undetectable because it's dormant. It's hiding out and could come roaring back at any time. "