Has anyone else been diagnosed with aggressive low-PSA prostate cancer?
Community Member
2 months agoI was diagnosed in February with stage four oligometastatic prostate cancer, a Gleason score of 8, but only one lesion outside the prostate, at the time of the telling MRI my PSA was 1.4, six weeks later it was 1.2, Urologist says it's a one in a thousand case, very aggressive cancer that produces very little PSA, I was seeing the Urologist annually because of another issue and he always did the DRE, that's when he discovered a lesion on the prostate, the lesion on my iliac bone has been successfully radiated, I've been on ADT therapy along with abiraterone and Prednisone for three months, my PSA is down to .21 and my testosterone is at 7, so far no pain at all, the general consensus from my "team" is ill be lucky to make five years, I've changed my diet and I adopted a vigorous exercise routine, I'm taking meds to counter the emotional jags of no testosterone and a sleep aid because I wasn't sleeping but 2 or 3 hours and some nights none at all. After much debate they have agreed to radiation for my prostate, I know there are risks but I'm at Dartmouth Hitchcock medical center, it's a top notch NCI rated facility, honestly it's really about revenge for me, I want to kill the crap that's killing me, it sounds silly but that's how I feel. Anyone had a similar diagnosis?
Community Member
2 months agoThis diagnosis combination sounds incredibly challenging, and the feelings about wanting to fight back are completely understandable. While low-PSA aggressive prostate cancer may be uncommon, there are others in similar situations who have navigated this path, and hopefully some community members will share their experiences with you. The comprehensive treatment approach and the support team at a quality medical center can make a real difference in outcomes, and it's encouraging to hear about the positive response to treatment so far.
Community Member
2 months agoI was diagnosed Stage 4 March 2023. Gleason 4+5 PSA 3.2 three pelvic nodes. Eligard plus Aberaterone then 28 sessions proton radiation. Ended ADT June 2025 PSA 0.02 testosterone 0. Now PSA 0.11 testosterone 188 still feel effects of hormone therapy. ED no sex drive muscle atrophy even with weight lifting three x per week weight gain in mid section ( very annoying) Radiation had significant side effects proctitis etc mostly resolved after 4-6 months Will be having PSMA PET/Ct regularly if / when PSA hits 0.5. Best of luck
Community Member
a month agoI was surprised to see that your “team” estimated life expectancy. My oncologist refused to answer. That said, I was diagnosed with PSA 11.5, Gleason 9, node positive, 95% of cores positive in 2018. 7+ years on my PSA has remained <.1 since early in treatment. 3 years ADT concurrent with 2 Zytiga and 45 days of radiation (81 Gys) have left me feeling well and grateful. That said, I endured all the usual effects of my treatment, plus some less common, for which surgery was required. I can’t predict your course, but can offer hope for more than 5 years.
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