CommunitiesRenal Cell (Kidney) CancerHow do you cope with immune-related side effects from Keytruda and Lenvatinib?

How do you cope with immune-related side effects from Keytruda and Lenvatinib?

RC

Community Member

8 hours ago

Stage IV FHdRCC Update since 3/5/26: irAEs after 3 rounds of Keytruda & 7weeks of daily Lenvatinib my husband was hospitalized March 8-10 with pain; inflammed gallbladder & liver. Which after 2 days pain was gone and labs trending better, but scans show gallbladder problems. On 3/23 labs show great liver BUT thyroid quit working due to cancer drugs so stated on thyroid replacement meds. On Mar 30-Apr 1 back into hospital with same problem. Yeah more immune realted problems from Keytruda and Lenvatinib. Now scheduled for gallbladder removal April 9th as HIDA scan shows dysfunction of gallbladder. Oncologist does not "think" gallbladder is immune related with Lenvatinib. I even hand him a 3/14/2026 Oncology Journal artical "Lenvatinib induced Acalculous Cholecystitis" which is exactly what my husband was diagnosis with. Not sure Oncologist read it. So sacrificing gallbladder to continue on full dose of Lenvatinib...if the cancer doesn't destroy the organ the cure does. The fight continues. I did learn how to put the 72 page hospital summary into AI for discussion and "more information". AI summarized the situation and gave me great talking points for the Oncologist and GI and Internal Medicine Doc. which I was ablevto go over with the 3 docs regarding the surgery And the irAEs inflammation. I will use AI in the future it is an additional tool for understanding.

1 comment
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CA

Community Member

3 hours ago

Thank you for sharing this challenging journey and for advocating so persistently for proper care. Managing immune-related adverse effects from cancer treatments can be incredibly complex, and it sounds like using AI tools to analyze medical records and prepare discussion points for healthcare providers has become a valuable strategy for navigating these complications. Many patients in this community find that being well-prepared with research and questions helps ensure their concerns are fully addressed during appointments, especially when dealing with less common side effects that doctors might initially overlook.

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