Which chemotherapy treatment has fewer side effects: A/C keynote 522 or T/C regi...

Hi Charlene, For my aggressive but tiny triple negative cancer with regional metastasis to one axillary node, and requiring a double mastectomy due to the hi Ki score, I was first treated with 3 months as weekly treatments of Carbo/Taxol, followed by 3 months or treatments every 2 weeks, of Adriamycin/Cytoxan. Yes, side effects occurred with all treatments but your Oncologist and team will make the treatments very tolerable. Stay active and keep a positive, warrior attitude. I had a lot of fatigue, weakness, hair loss, nausea, rashes, anemia, low white cells, low platelets, sore eyes, etc. but I was treated accordingly and learned many dietary tips. After more surgery to remove the node, I had oral chemo, Xeloda, for 3 months at a high dose and now I’m on Lynparza, a PARP inhibitor, because of my inherited BRCA 2 genetic mutation. I am not a candidate for immunotherapy like Keytruda, because of having 5 autoimmune problems and the risk of death. I’m keeping very active, walking 10 miles a day or more, and keeping busy with social activities as able. I’m wishing you the very best on your journey. My real journey began when I unexpectedly metastasized after the double mastectomy that initially had clean breast margins and nodes. That was found 10 months post op and than, Chemotherapy was necessary. A very difficult time for me. Again, praying for you as you begin your journey. 🙏

Thank you ! Seems like you really had a lot more to deal with I so appreciate your feedback and will keep you in my prayers you are the true meaning of a warrior ! I hope I can find that strength you have .

We are given the necessary strength through God, and I feel the approach is to take one day, one treatment regime at a time. I never anticipated needing any treatments. I was told that the initial surgery “removed all cancer that was unusually very small,” not requiring treatments. Oncology explained the aggressive nature of triple negative cancers, the unusual aggressiveness of mine with a 95 Ki score, and very close monitoring. He felt that the cancer had remained in my blood post op, undetected, as tumor markers were mildly elevated but scans were negative initially. I’m just happy that I am tolerating necessary treatments, and keeping optimistic. 🙏

I’m very happy your tolerated the treatment and you have the courage and strength you need to do so . I will pray for you for a full recovery ❣️🙏🏻

Charlene, Thank you and God bless 🙏❤️

Stage 2 TNBC diagnosed in November and I didn’t get the A/C because I had a relatively low Ki score and my Dr said I have a subtype called LAR which doesn’t seem to respond to the A/C. I had Carboplatin, Taxol & Keytruda, but didn’t get pCR, so now I’m on Xeloda and getting Keytruda. Hoping for the best. Good luck! I had very few side effects with my treatment.

Best wishes and prayers, Claudia.

I wish all of us good luck. I pray for God’s healing touch. Let’s stay strong and positive

Treatment decisions like these are deeply personal and depend on many individual factors that only your oncology team can properly evaluate. Both regimens have different side effect profiles and effectiveness rates that vary from person to person based on specific tumor characteristics and overall health. Consider bringing a list of your specific concerns about side effects to your next appointment so your medical team can help you weigh the benefits and risks of each option for your particular situation. Other community members who have experience with these treatments may also share their perspectives here.