Seeking Others with Triple Negative Metaplastic Breast Cancer

Hi Dawn I had triple negative stage 2B no lymph node involvement had 4 treatments of doxirubicin And Cytoxan then 16 treatments of Taxol then lumpectomy found one lymph node cancerous. Just started 23 radiation treatments will start Zoloda chemo drug after that for 5 months more Doing well

Dawn- I am also on the triple negative face book site and saw several ladies post about being Metaplastic. I had never heard of it but quickly looked it up.

It’s very rare apparently. My treatment is still the same as just TNBC.

Please connect with those ladies on the TNBC survivors fb site

Thank you

I was dx Metaplastic, inflammatory TNBC stage 3A then later metastatic to lung. I've been NED since February 2018. I hope this encourages you! I also recommend joining the TNBC FB group. I used to be in it until stage 4 dx, then I was transitioned to the Stage 4 group.

I did join. Thank you

I have triple negative stage 2 no lymph involvement had 8 round of chemo treatment I am have a hard time with the side effects.

I'm TNBC stage 3 bilateral mastectomy and cancer free since 2022, got any questions I'm here.

I was just diagnosed with Metaplastic Carcinoma Stage 1A (5mm spot) during my preventative mastectomy. Triple negative. Sentinel mode biopsy came back negative. Waiting to talk to oncologist about therapy. He had said we could treat the triple but there are no known protocols for metaplastic.

And that’s the crazy part. The metaplastic is rarer than triple negative.

Yep I'm not sure what to do now. Caught early but would love to do whatever I can to up my chances of a good prognosis. Not sure if that's chemo or radiation

Hi Dawn, I was also eventually diagnosed with stage 3, triple negative metaplastic squamous cell carcinoma. I was initially diagnosed in October 2024. The biopsy results indicated invasive ductal carcinoma. I had genetic testing done and everything prior to starting chemo, which started 3 weeks after diagnosis. I'm negative for any inherited mutations. The tumor itself had a P53 mutation. So, long story short, I was put on the keynote 522 protocol, which entailed weekly taxol and carboplatin, along with Keytruda. My tumor kept growing on chemo and a month after starting, I brought it to my oncologist and surgeon's attention. I was moved to emergency surgery for a mastectomy, as the tumor had encompassed my whole breast by new year. My surgery was that week. Once pathology came back for the tumor, it was revealed to be metaplastic squamous cell carcinoma (still triple negative and had a P53 mutation)- not invasive ductal cell carcinoma. So that is a clue as to why it grew so fast and didn't respond to the chemo. Sentinel node biopsies were clear. But the tumor had attached to my chest wall when it grew while on chemo. After I got done with the mastectomy, I had to move to the next phase of keynote, which is doxorubicin and cytoxan for 4 doses. I couldn't get through them. Each dose landed me in the hos with neutropenic fevers, even with dose reductions. We had to stop chemo. I am now in the radiation phase for the chest and along the incision. 6 weeks daily radiation. Then I'm told I'm supposed to start capcetibane for six months after radiation is complete. I know it is very rare and already tnbc is aggressive, making it one of the most aggressive of the aggressive subtypes. I've never met or come across anyone with the same diagnosis and am also my oncologist's first patient with this profile. Would love to hear from others as to how they treated it and if there are any long term survivors. Thanks

I started 4 cycles of TC chemo this week. With mine being stage 1 at 5MM with no nodes, they believe it is gone but are treating for reoccurrence at this point.

I have triple-negative metaplastic breast cancer. Had a lump removed then chemo and radiation right after. I have little to no immune system because I also received a pancreas transplant and am taking autoimmune drugs daily. Does anyone know the life expectancy for this type of cancer?

Finding others with metaplastic breast cancer can provide valuable connection and support during treatment. This rare subtype within triple-negative breast cancer affects a small percentage of patients, which can make the journey feel isolating. Connecting with others who understand this specific diagnosis through support groups or online communities can offer both practical insights and emotional encouragement as treatment progresses.