What side effects should I expect from Keytruda and Lenvima treatment?

What stage was your cancer and what! type? Mine was stage 1a grade 1 a endometrial cancer with a small tumor that had stayed within the uterus wall.. hopeful that after a full historectomy that my cancer is gone. I'll have my 6s week check up in April. I wish you the best. Getting started with treatment will be good. It helps the fear factor leading up to it. Not knowing what will happen is hard. My heart is with you

Thank you so much for your kind words, Jennifer! My uterine cancer was diagnosed as stage 1, 3c. My surgeon really thought it was all contained and had not spread to my ovaries, cervix, fallopian tubes, or any surrounding areas. Like for most of us, the chemo and radiation were to make sure it had not spread. We are devastated, to say the least. We are truly praying for the best. My heart goes out to you, as well. Praying for your healing!!! ❤️‍🩹

Starting a new treatment can feel overwhelming, especially after everything you've already been through. While side effects can vary greatly from person to person, many patients do find ways to manage them successfully with their care team's support. Consider discussing your specific concerns with your oncologist before Friday - they can share strategies to minimize side effects and help you feel more prepared. This community has members with experience on similar treatment combinations who may share their perspectives, so hopefully you'll hear from others soon about what has worked for them.

What is Lenvima ?

Hi JoAnn, Lenvima is a targeted type of therapy, and is a type of chemotherapy that you take every day in pill form. The Keytruda is an Immunotherapy type of drug that you receive an infusion every 3 weeks. I got my first dose of Keytruda yesterday. The Lenvima pills arrive next week due to my insurance denying coverage for several weeks. I’m praying I can tolerate them both as they can have horrific side effects. I wish you the best! ~Suzanne 🙏

Keytruda works to super charge your immune system against the cancer, but it can often cause your immune system to start attacking other organs too like it did me. Log everything and report all symptoms to your Dr. I did much studying and have come to look at cancer as a metabolic disease. I am starving my cancer by targeting the pathways of glucose, glutamine , and fatty acid metabolism along with inflammation through diet, exercise and targeted supplements. I am healthier today than I have been in years even after chemo and with a stage IV cancer and by God's grace celebrating two years of remission. Suzanne, I will pray for you.

Hi Dongeo, I’m praying for you, too! I had my second Keytruda infusion yesterday; right now, every 3 weeks. Was told I’ll be on it the rest of my life!!! My blood pressure went up quite a bit; they had to double my med. for that. It’s better, but more tired, achy, and other bothersome but tolerated symptoms. I start on Lenvima pills today; was told a lot more side effects. Stanford surgeon calls it Stage I, 3b, even though endometrial cancer has spread to my lungs. Oncologist calls it Stage IV. We’re praying for the best for everyone!!! 🙏💜

Hello Everyone. New to the group. Serous carcinoma of endometrium stage Ii in 2022. Now stage 4. Oncologist did no scans for 1.5 years between remission and Mets in lung and lymph. I had to ask for scans in July 2025. I have 2 questions. 1. What does cavitation in the lung tumor mean? Does that mean the Lenvima and Keytruda are working or not? 2. Should I fire my oncologist for the time lapse?

Hi Kay. You should have been at a minimum having a scan every six months. Usually for the first two years you are monitored every three or four months. Depends on the stage. I would look at getting a second opinion. Your question as to meaning is that the tumor has developed a gas filled space due to some necrosis, which would be good if it's the tumor dying off. Make the Dr explain it.