Has anyone tried ctDNA blood test for cancer monitoring?

The ctDNA blood test is becoming more common for cancer monitoring, and many patients find it helpful as an additional tool alongside imaging scans. It sounds like you're taking a comprehensive approach to monitoring with both the PET scan and this blood test, which can provide valuable information to your medical team. Hopefully other community members who have experience with ctDNA testing will share their insights to help answer your question about how the process went for them.

I have 2 ctdna tests and both were negative. I've also had 3 NEAD ct scans. I have Stage 4 uterine cancer (since 2023). I've been on Enhertu for almost 18 months and it's been a game changer for me.

Thanks I'll look up the med

Anonymous user can I ask if you are now considered cancer Free after 2 negative ctDNA ? Is the enhertu maintenance. Stating you have stage 4 I'm a little confused where you are now. Thanks for commenting too

Also nead scan does not come up. But head ct does. Sorry. Looking for answers

Neg I think?

I'm not sure why it's posting as anonymous - my name is Laurie btw. Nead means no evidence of active disease. Even though i'm stage 4, they can't see any evidence of cancer on ct scans or on the ctdna because enhertu has done such a good job of suppressing it. I will be on enhertu forever or until it stops working. They know with my cancer being stage 4 that it's still lurking even if they can't see it right now.

Thank you Laurie. Glad it's working for you.

I may be at the stage if nead and seeking maintenance drug. Can't use what you are using. So team looking for new approvals soon

Best of luck!

Thanks Laurie!

I'm in Cleveland clinic main campus in a study with. oncology. If you want to share where you are being treated I'd be interested too. Thanks. No pressure.

GOG 3104 is a Phase 3, randomized clinical trial evaluating the efficacy and safety of sacituzumab govitecan (SG) compared to physician's choice of treatment (either doxorubicin or paclitaxel) in patients with recurrent or persistent endometrial carcinoma or carcinosarcoma. The primary endpoints of the study are progression-free survival (PFS) and overall survival (OS). The trial aims to determine whether SG offers superior clinical outcomes compared to standard chemotherapy options in this patient population.   This is my study started last June 25. Igot taxol instead for chemo and did great with it 3 years ago and again. I could get sg when it wins approval for maintenance

Interesting! I'm being treated at Dana Farber. Not in a trial.

Thanks

Ther was a great article on using ct dba with endometrial cancer in this site

Ct dna

I finished chemo February 29, 2024, for my stage 4 endometrial cancer and also could not take the Keytruda. I was having CT scans then was switched to PET every three months to monitor for metastatic disease. The PETs were negative. Out of my concern for the cumulative effects of radiation and the cost, my oncologist suggested the NATERA blood test. The first time takes a while for results because the lab has to obtain and work up your original biopsied tumor sample. I just had my second blood draw.

I saw that sg will not be used to maintain. But in new cases. My doc will inform me of ways to maintain cancer free when I get there

Are you saying that they won't continue to give you signatera tests?

I will get ctDNA every three months until they say they don't want.

Results came back all negative. I am grateful.

Yay!

Hi Laurie , what a good news . Did they did hysterectomy for you . I have stage 4 endometrial cancer with peritoneal metastasis and pelvic lymph nodes , I consulted 2 surgeons and they said , surgery will not be be official in my case

@Dongeo, Hughes , did you do for removing uterus and ovaries , your case is line mine and I consulted 2 surgeon at Dana Farber and they mentioned is not beneficial for my cas and they consider second lie chemo with doxil qn darboplatin and they are considering clinical trial