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Which hormone therapy option did you choose for ER+ breast cancer under 40?

Community Member

7 days ago

I have hormone receptor-positive breast cancer and my oncologist explained two main endocrine therapy approaches. One option involves inducing menopause first and then using hormone-blocking medications. The other uses hormone therapy alone without changing my menopause status. Both aim to block the hormones that can fuel cancer growth and reduce recurrence risk. I'd love to hear from others who faced similar decisions about their experiences, especially anyone who was ER positive, PR negative, HER2 positive, had a mastectomy, completed TCHP chemo, Radiation, a a full year of Fesgo shots and was younger than 40 at diagnosis. I’m currently 39. • If you had hormone receptor-positive breast cancer, which endocrine therapy approach did you choose and how did you make that decision? • What was your experience like with whichever option you went with?

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Community Member

7 days ago

Making endocrine therapy decisions at 39 with hormone-positive breast cancer involves weighing complex factors that can feel overwhelming. Many community members have navigated similar crossroads between ovarian suppression combined with hormone blockers versus tamoxifen alone, and their shared experiences often highlight how personal circumstances, side effect tolerance, and long-term goals all play important roles in the decision-making process. Connecting with others who have similar tumor characteristics and treatment history can provide valuable insights as you work with your medical team to determine the best path forward.

Community Member

4 days ago

Hey Callie, I’m Marti. Was diagnosed HR+ HER2 neg/low and node+ breast cancer in January 2025. I’m 35 yo and in full blown menopause. I am on verzenio 2x/day, anastrozole 1x/day and monthly zoladex implant. I don’t have a period anymore. I get pretty emotionally dysregulated for a couple days around the zoladex injection. The verzenio took some time to regulate/balance with my digestive system. (Best for me, I take half an Imodium every morning). And I have hot flashes regularly- multiple times a day (they are a little worse around my injection) but I am actively experimenting with nutrition to find an overall physical balance. The recurrence percentages were most encouraging of my decision and then lack of interest in having kids kind of sealed the deal for me to continue with this oral regimen. I did get curious about an oophorectomy instead of the pill/injection combo of ovarian suppression bc of convenience/ duration of side effects but have not moved forward with surgery. Here to answer if you have any more questions or curiosities. Marti

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Which hormone therapy option did you choose for ER+ breast cancer under 40?

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