CommunitiesBladder CancerWhat clinical trials or treatments are available for metastatic urothelial cancer?

What clinical trials or treatments are available for metastatic urothelial cance...

JR

Community Member

a month ago

Seeking any recommendations/advice about other clinical trials, treatment plans, other considerations we can explore.. My wife Jacki has urothelial cancer (originated in the kidney rather than the bladder) that has metastasized to her lungs, liver, rib/hip area. She had her kidney and adrenal gland removed at MD Anderson last January. The following are the treatments she has endured so far: October 2024 thru December 2024- Cisplatin, Gemcitabine and Immunotherapy (Nivolumab) UC Davis Cancer Center January 2025 Kidney and Adrenal Gland Removal MD Anderson March 2025 thru May 2025 Ketruda and Padcev UC Davis Cancer Center July 2025 thru September 2025 Clinical Trial Study called REJOICE at MD Anderson consisting of Raludotatug Deruxtecan (R-DXd) October 2025 thru January 2025 Cetuximab UC Davis Cancer Center The Cetuximab showed promise during the initial 6 week treatment plan targeting EGFR. However the next 6 week unfortunately showed the tumors had grown in size. Seeking your help, guidance to beat this nasty disease!! Thank You!!

5 comments
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CA

Community Member

a month ago

Thank you for sharing this journey and reaching out to the community for support and guidance. The path taken shows incredible strength and determination in exploring various treatment options across multiple respected cancer centers. For metastatic urothelial cancer, clinical trials often provide access to cutting-edge therapies, and resources like ClinicalTrials.gov, the National Cancer Institute's database, and cancer center websites can help identify current studies. Many community members have found value in seeking second opinions at comprehensive cancer centers or consulting with oncologists who specialize specifically in urothelial cancers, as they may be aware of emerging treatment combinations or newer targeted therapies based on specific tumor characteristics. The cancer community here understands how challenging this journey can be, and many members have valuable insights about navigating treatment decisions and finding hope during difficult times.

GG

Community Member

10 days ago

I have the same cancer. Penn medicine gave me everything they had. Each worked for awhile then cancer spread to my liver. I am now in a study at Sloan Kettering in nyc. My gremlins have shrunk 40%. I suggest calling them. Dr Iyer. The study pays for your travel. There may be a Dr closer to you that has this infusion. It’s made by Lily.

JR

Community Member

10 days ago

Thank you Gerrie for the recommendation. Do you know the name of the Lily treatment study you received?

GG

Community Member

10 days ago

I’m on LY4052031 made by Lily pharmaceuticals. I was previously on another one of their studies LOXO 435 it work for awhile and then stopped. This one has the doctors very excited.

JR

Community Member

10 days ago

Great to see the Lilly trial is having success for you. Thank you for the trial info.

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