Are Signatera results supposed to fluctuate with stage 2 bladder cancer?

Signatera test results can indeed vary, and fluctuations are not uncommon as the test is designed to detect very small amounts of circulating tumor DNA. Many bladder cancer patients report seeing changes in their numbers over time, which can understandably cause anxiety. Consider discussing these fluctuations with your oncology team, as they can help interpret the results in the context of your specific situation and treatment plan.