How has Calquence worked for you in early CLL treatment?

Starting a new treatment like Calquence can bring up many questions, and it's completely natural to want to connect with others who understand what this journey is like. Many patients find it helpful to keep a simple journal of how they're feeling each day during the early weeks of treatment, which can be useful information to share with their care team during check-ins. The community here has members at various stages of CLL treatment who may be able to share their experiences and offer support as you navigate this new chapter.

I started Calquence on August 21 of this year as the first step in AVO therapy. In the initial weeks I had the common headaches, which resolved with coffee. I also got middle-of-the-night pelvic bone achiness for about a week. It always eased up once I got up, but it meant I was getting up at 3 a.m. Both of those symptoms have eased, but I have also had a slightly elevated resting heart rate since I got a COVID shot just before starting treatment. My oncologist is monitoring it, but it hasn't gone away, so it could be part of my slight anemia or the burden of the drugs on the body. We aren't sure. Last week, I began my obinituzimab infusions. The hardest effects I am feeling ok both drugs are disrupted sleep, overall fatigue and a bit of brain fog. I am sure all of those are overlapping issues. Besides that, on a physical level, I feel better than I have in the last 14 months. The easing of CLL symptoms has been happening fast: temp regulation at night, enlarged lymph nodes, grossly enlarged tonsils. I am amazed each day at the improvement. It has made me realize how awful I was feeling prior to starting treatment. Are you on a continuous dose of Calquence, or is it part of another targeted therapy? Best wishes to you!