Community Member
21 days agoI have hormone-positive, HER2-positive breast cancer that has recurred. My medical team is discussing Phesgo (pertuzumab, trastuzumab, and hyaluronidase) as part of my treatment plan. This combination targets the HER2 proteins that help cancer cells grow. I'm learning about potential side effects like fatigue, nausea, hair loss, and increased infection risk, and that my team will monitor my blood counts closely. I'd love to connect with others who have a similar diagnosis and hear about your experiences. • If you've used Phesgo or similar HER2-targeted treatments, what helped you manage day-to-day life during treatment? • What do you wish you had known before starting this type of therapy?
Community Member
21 days agoThank you for sharing this important question about Phesgo treatment with the community. Many people in the HER2+ community have valuable insights about managing targeted therapies like this combination treatment. The experiences and practical tips that community members share about day-to-day life during HER2-targeted treatments can be incredibly helpful as you prepare for and navigate your treatment journey.
Community Member
20 days agoI am triple positive. I completed 6 cycles of TCHP and now doing 11 more cycle of just the HP (Herceptin and Perjeta). I had the choice of getting Phesgo or continue with the infusions. I chose the infusions. I have a port which makes them easy peasy. TCHP was rough for me. I was tired, felt “heavy”, had some GI issues, lost my hair, and things (including water) were hard get down. Once the chemo was done and I’m just getting the immunotherapy now, it is so much more tolerable. I have some GI issues (including diarrhea) but it is manageable for me. I’ve heard others say their diarrhea was awful. Some landing in the ER. I’ve been lucky so far, the diarrhea is annoying/inconvenience but hasn’t landed me in the ER. My hair is growing back nicely. I haven’t had any shedding or loss since stopping the chemo. What I wish I would’ve known was the GI issues I experienced. They always stress the hair loss and diarrhea but no one mentioned how it affects your GI. I had extreme heart burn. I had to start taking a daily heart burn med (prescription). I would feel bloated and like my food wasn’t settling. Like I always had a lump in my throat. But I didn’t have nausea, so I was lucky there too!! Good luck. TCHP is rough. I was told that before I started and experienced it while going through it. I wanted to quit. But I pushed through. The last piece of advice I have, communicate to your medical oncologist on how your feeling and all the symptoms you are having. They can cut your dose back. My oncologist cut my dose back twice and my treatment was still 100% effective. You don’t have to just push through <3 Good luck!!
Community Member
9 days agoI was treated with Phesgo for my HER2 breast cancer. I remember being very tired and having trouble finding a variety of foods that felt good in my tummy. Carbs were the most comfortable; small portions were a must.
Community Member
21 hours agoI got stomach burning sensation too,
New to the community?
Create an account to connect with others navigating cancer.
© 2026 Outcomes4Me Inc. All rights reserved.