Has anyone tried GLP-1 drugs for letrozole weight gain during cancer treatment?

Weight gain during cancer treatment can be incredibly frustrating, and it sounds like discussing GLP-1 options with your endocrinologist is a thoughtful next step since they'll have expertise in metabolic treatments. The challenges you're facing with provider and facility changes on top of treatment side effects must feel overwhelming - many others in this community have navigated similar disruptions and may have helpful insights to share about both weight management strategies and finding continuity in care.

I have started a GLP-1 to reduce both my cancer risk and also my heart disease risk. I am soon to be 70. I have lost 25 pounds and feel fabulous. Not looking to lose any more weight. I wasn’t willing to take hormone blockers— I already was overweight, had joint pain, osteopenia and a dry vagina. The GLP drugs were a better option for me.

I have been on a GLP-1, Mounjaro, since October of '24 to see if it could help me lose weight and improve my diabetes and heart concerns. I lost about 30 lbs. I have been on my breast cancer journey since June '25. I am taking Anastrozole and have been successful in losing about 35 lbs since my DMX in October of '25. It is worth discussing with your endocrinologist and I wish you the best in your journey.

I discussed it with my endocrinologist and he said that when you’re dealing with cancer, you get one chance and if you come out on the other side, not to mess with anything. Really???? Time to get a new endocrinologist. So tired of all of this

Wow so sorry to hear of your experiences with all of this.

I believe GLP1 's have been shown to cause thyroid cancer in mice? Not sure if it's been studied in people yet? I suspect in a few years we are going to hear about many long term side effects. The choice must be yours and yours alone. Every RX has risks!

GLP-1s have been prescribed for ~ 20 years. Risk/ benefit for each individual is the key. I love hearing a variety of perspectives so I can do further research.

There have been several positive clinical trials with GLP1 & hormone/ endocrine therapy. Mayo Clinic has some excellent resource about this topic. The newest studies even show that it helps to be similar to a hormone blocker and helps to reduce the reoccurrence of cancer. My oncologist recommended it because the hormone therapy tends to make people gain weight I just started so I don’t have a lot of experience under my belt, but I am keeping a daily post on my YouTube channel. CancerChristi

GLP-1 receptor agonists (e.g., Semaglutide) are being investigated as an adjunct, not a replacement, for aromatase inhibitors in breast cancer patients with obesity. These medications significantly aid weight loss and metabolic health, which can improve prognosis and make hormonal therapies more effective. They work by suppressing appetite, not by blocking estrogen production like aromatase inhibitors. Key Considerations for Using GLP-1s in Breast Cancer Care: Not a Replacement: GLP-1 agonists (e.g., Wegovy, Zepbound) are generally used alongside, not in place of, standard endocrine therapy, to address obesity as a risk factor for recurrence.