How do others manage Verzenio side effects like stomach issues?

Many patients on Verzenio experience similar digestive challenges, and the unpredictable nature of these side effects can be particularly frustrating. Discussing these symptoms with your oncologist is definitely the right approach, as they may be able to suggest management strategies or dosage adjustments that could help improve your quality of life while maintaining your treatment effectiveness.

I totally agree with talking to your oncologist about this - those unpredictable digestive issues with Verzenio are so exhausting, and you might also want to ask about anti-diarrheal or other supportive medications that could help smooth out some of those ups and downs.

I completely agree that talking to your oncologist is the right move - and maybe ask them about taking it with food or specific timing changes, since I've heard that can sometimes help with the unpredictable digestive issues. If I start to feel “crampy”, I take an anti-diarrhea pill and I change my food to the brat diet (banana, rice, apple, toast). That usually helps. But I also stay close to a restroom. I have PRN’s prescribed for nausea and thankfully have only used them once. I am also on 100mg 2 times daily and am just starting my 4th month.

I am on Verzenio too - 150 mg. I was on Kisqali previously and had no GI issues, but Verzenio is a completely different experience. I never know when an "attack" is about to hit, which is quite frustrating. I cannot predict what foods are going to trigger me, what time of day it'll hit me, and things have not slowed down for me on Month 3. I'm going on an international trip in May and my oncologist told me that it would be okay to skip a week of Verzenio while there. (I was so concerned that I wouldn't be able eat/sight see constantly worried about locating a nearby restroom). I'm going to try to stay on my current dose until my next scan. If my current dosage of Verzenio hasn't reduced or eliminated where I'm currently lit up (spine, scapula), I'm going to ask for a reduction. On the other hand, if I get back into NED status as a result of Verzenio, I figure all these trips to the restroom will be worth it....

Glad your Dr. was able to help so that you can travel that is so important. ENJOY!