Is your CA125 fluctuating on Keytruda and Avastin?

Tumor marker fluctuations during treatment can be concerning, and it's completely understandable to want to connect with others who might have similar experiences with this treatment combination. Many factors can influence CA125 levels during ongoing therapy, so discussing these patterns with the healthcare team can provide valuable insights about what these changes might mean in the context of the overall treatment response.

What is a marker

Most cancers have an antigen that is in the blood that relates to a particular type cancer. Doctors watch this to see if treatment is working or severity of disease or other symptoms related to their cancer. For ovarian cancer it is marker CA 125,

I had 6 rounds of chemo/Taxol & Carbo/ after that I started December 2025 Avastin , which they said I’ll be on every three weeks for two years When I had cancer all my blood tests of CA125 (3-5 ) tests were all NORMAL! The only tests that where high were HE4 and AFT(Alfafeto tumor marker) If I were you, I would ask your doctor to test those two blood test. They were only ones that were positive on me when I had cancer. I wish you lots of luck❤️❤️❤️ Lannie

Hi Lori. I'm starting that regimen next week and will let you know what happens. Have you tolerated the Cytoxan well? I'm a little nervous about that drug.

Hi Lori. I just started the same regimen and will get my CA-125 in 1.5 weeks, at treatment #2. (For some reason, they didn't provide my CA-125 at my first treatment, although it was trending upward right before.) I'll let you know what happens. I'm tolerating the regimen pretty well and hope you are too.