Has anyone experienced conflicting HER2 test results after breast cancer surgery?

Communities›Just Diagnosed With Breast Cancer›Has anyone experienced conflicting HER2 test results after breast cancer surgery?

ME

Community Member

a year ago

After surgery, diagnosis was E+P+and HER2 ambiguous. Then determined HER2+. Was expecting to join a clinical trial with Kadcyla supposed to start next week. Now, I have Tuesday appt with onc to discuss treatments. When I asked onc asst why, she said the cancer was found to be + then - (it was about six tests with alternating results, just back and forth.) Wondering how they can be sure this is the right answer. The asst said the last person is the authority, very qualified. But still makes me wonder if I’m going to be treated for the right cancer. Anyone else run into this? Thanks!

5 comments

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Accepted Answer

Conflicting test results can definitely feel unsettling, especially when treatment plans are involved. HER2 testing can sometimes produce borderline or inconsistent results, which is why multiple tests are often needed to get a clear answer. The medical team's approach of running additional tests shows they want to ensure the most accurate diagnosis for the best treatment plan. Many others in this community have navigated similar uncertainty with test results, so sharing experiences here could be really helpful for everyone facing these situations.

3+ patients found this helpful

JG

Community Member

7 months ago

Get a second opinion.

1

ME

Community Member

7 months ago

Thank you for the common sense! I got so caught up in confusion that it never occurred to me. My best to you!😊

CP

Community Member

7 months ago

I would get a second opinion. Send tissue samples out. I have two cancers. One is E+, the other triple negative! That may explain your situation.

ME

Community Member

7 months ago

Hi Carol, that seems like a drastic and concerning difference. Thanks for the input. I hope yours gets sorted to where you feel confident. And things get easier. All my best, Megan

CA

Community Member

2 months ago

Conflicting test results can definitely feel unsettling, especially when treatment plans are involved. HER2 testing can sometimes produce borderline or inconsistent results, which is why multiple tests are often needed to get a clear answer. The medical team's approach of running additional tests shows they want to ensure the most accurate diagnosis for the best treatment plan. Many others in this community have navigated similar uncertainty with test results, so sharing experiences here could be really helpful for everyone facing these situations.

Has anyone experienced conflicting HER2 test results after breast cancer surgery...

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