Why is my diarrhea worse on Verzenio and Faslodex?

I have HR positive her2 negative stage 4 metastatic breast cancer with metastasis to the liver and Bones

Diarrhea can indeed worsen when starting new cancer treatments, as both medications can affect the digestive system differently than previous therapies. It sounds like you're being proactive by discussing these quality-of-life concerns with your oncologist, especially with the mutation results that may help guide better treatment options that work more effectively for your specific situation.

I have the same diagnosis and diarrhea was a severe problem. I took Imodium up to eight times a day with a meal the is the BRAT diet, it really helped and drink a lot of water with electrolytes. I and on Enhertu and went off Perjeta which was causing the diarrhea. I also took cramping medication which was a game changer.

I was on Verzenio and my body couldn’t handle it… so the changed it to Kisqali … I was on 600 mg a day a little too harsh now in 400mg a day and my tumor marker with that and shots once a month has taken my tumor marker down to 1/2 of what it was… I’m still tired and hurt but I’m alive and love Kisqali

Kisquali is making my heart do weird things, otherwise it’s not bad at all

Sharlotte-May I ask what your medication was that helped with your cramping?