Switching Between Different CDK 4/6 Inhibitors?

I just started my 2nd month of Kisqali & will get my faslodex injections monthly now. I had to get it 3 times, 2 injections at the same time, 2 weeks apart & now monthly. I go shopping for supplies so I can do a lot of walking after the shot. It really helps you not to get sore. So far, I feel good & my labs have been good. Hopefully, my CA 27-29 starts coming back down. This is my 2nd treatment. Good luck on your treatment!

How is the combination working Kisquali + Letrozole ?

I was on Ibrance but switched to Verzenio due to unmanageable side effects. Had a good run with Verzenio/letrozole/xgeva. Developed ONJ due to Xgeva so was on Verzenio/Letrozole for a year more. Verzenio/letrozole failed earlier this year so went on Orserdu which failed as well. Then to Xeloda which has failed again. Starting Abraxane on 11/21 and will go from there. It’s been a crazy year for meds for me.

I was in verzenio/letrozole/xgeva and progressed and will be starting kisqali/fulvestrant/zometa when I get back from vacation. Anybody who has been on kisqali/fulvestrant/zometa, I would love advice re: side effects.

I started on Ibrance, letrozole, Xgeva for about 3 years. I had disease progression, Mets to my skull. Had radiation to my skull and switched to Ibrance, fluvestrant, Xgeva. That lasted about 4 years. This last year I'm on Kisqali, exemestane, Xgeva. My last scan showed Interstitial Lung Disease which can be a side effect of Kisqali. But, I'm still on it. Waiting on my next scans. I also now have CKD stage 4. Praying I'll get a few more years.

I was on Ibrance, Aromasin, and Xgeva for four years. When I started having progression, I had the blood test to see if I had the ESR1 mutation, which I did. I started on Oserdu in fall 2023, and so far it’s being effective as of my 6/24 PET scan. It’s an extremely expensive drug, but thankfully my insurance has covered it. I also get Prolea injections every six months now.

I was on Kisqali/Fulvestrant and the Kisqali was too toxic so was put on Verzenio/Fulvestrant and I progressed on that. There was no mention of trying Ibrance but I wonder if I should have? My dr decided to have me try Truqap so I started that Friday and I hope it works

Usually I don't have many side effects from medications (Verzenio/fulvestrant). The Verzenio made me extremely fatigue and after 8 months it quit working. Now I take Truqcap, Fulvestrant, and Xgeva, and since August last year Tumors and Mets are stable. The side effects of Truqcap don't show up after the first dose, but after a few months the side effects show up. They include diarrhea, mouth sores, diabetes, and itching. Your doctor will prescribe some medication for you to manage them.

Many people in this community have experience switching between different CDK 4/6 inhibitors when one stops working effectively. Each medication in this class works differently in the body, so oncologists often try another option when progression occurs. It's great that you're thinking ahead and planning - having these conversations with your medical team about potential next steps can help you feel more prepared and in control of your treatment journey.