Has anyone taken Verzenio? What side effects should I expect?

Many community members have shared experiences with Verzenio, and it's completely understandable to feel concerned about potential side effects when switching medications. While experiences vary from person to person, connecting with others who have been on this treatment can provide valuable insights and support during this transition.

I’ve been on escalating Verzenio doses for 5.5 months now. I had no symptoms for the 200 mg and 250 mg daily dose except mild constipation which I manage with one stool softener a day. At the 300mg dose I seem to have some loose stool lately but never to the extent of diarrhea. I’m still taking the stool softener but consider phasing out this week. When I was diagnosed I had horrendous pain all over my body and needed help getting out of bed. Now I’m back to my Zumba, core and strength routine so I feel blessed for Verzenio and Faslodex (shots every 28 days).

Thank you, Ana! I'm very glad to hear this. I had my first shot of Faslodex today.

I insisted on full molecular screening to confirm I had no mutations (Guardant 360) since I had been on Letrozole for 13 years. I had the recurrence 3 years after I stopped Letrozole - wish I had stayed on letrozole forever. Thankfully I did not have any mutations. Many doctors discourage genetic testing at the start of treatment but for me it made total sense and not waste time while another drug could be doing a better job.

I just started Datroway . First infusion went well. I'm going for 2nd infusion this Thursday.

I have been on verzenio for about 6 months. Started with 50 mg twice a day. Now I am on 100mg twice a day. Lots of side effects, diahreah, constipation, upset stomach, indigestion. All that I’ve been able to deal with. The worst has been sleep. This dang pill keeps me from falling asleep and or staying asleep. I can’t be on this for 2 years without good sleep. My oncologyst will have to make a change here. I just hate to start on a new medication and go thru all the side effects again. Has anyone experienced sleep problems on verzenio?

Hi, Aleida. Sorry you are having such issues. I was on 5 mg of Ambien for the first 4 months of Verzenio - mostly for anxiety and pain from cancer in my bones. At month 5 I started weaning myself from Ambien since I felt almost back to normal from the cancer itself. Right now (2 months later) I’m at about 75% of my normal sleep pattern but hope to get better with time. Sleep is very important - maybe your doctor can prescribe a mild relaxant. I tried OTC stuff and nothing worked. Verzenio saved my life so I would have done anything to stay on it.

Kisqali I am on now.. they tried me on verzenio and the gi was awful. Diarrhea and you don’t feel it coming.. I know I didn’t.. Kisqali now for a while… just find I am getting weaker.. and no appetite