Community Member
9 days agoI have had multiple myeloma since 2008. Had a stem cell transplant in 2009. Have done well with maintenance therapy through the years. M spike started in the fall of 2025. It reached 1.4 in April so my hematologist ordered bone marrow biopsy and PET scan. Results show no lesions or bone/kidney damage. I feel okay but 15% of bone marrow is myeloma. He says I have relapsed myeloma. I have deletion of TP53 gene at 17p13.1 gain of chromosome 7 and 9, deletion of 13q and loss of IGH/14q, FGFR3/4p and MAF/16q. He says this will cause myeloma to be more aggressive. He is sending me to MM center at Univ.of Arkansas for further evaluation. I am a born again believer in Jesus Christ and a man of prayer but this is concerning to me. Can anyone "interpret" what the deletion of TP53 gene means? Is this an imminent death sentence or is there hope to put the myeloma back into remission? concerning to me
Community Member
9 days agoWhile TP53 deletion and other genetic changes can make treatment more challenging, advances in multiple myeloma care continue to offer hope for many patients, even with high-risk features. The University of Arkansas has extensive expertise with complex cases and access to cutting-edge treatments that may help achieve remission again. Many community members here have navigated similar genetic findings and found effective treatment paths - their experiences and support could be valuable as this journey continues.
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