Non-Small Cell Lung Cancer Clinical Trials

What's the best treatment for recurrent lung cancer?

I have large cell lung cancer that has returned locally. My oncologist mentioned several treatment options including surgery to remove the cancer again, definitive radiation therapy, or concurrent chemoradiation (chemotherapy combined with radiation given at the same time). I'm trying to learn more about what these different approaches might be like from people who have been through similar situations. I'd love to hear from others who have dealt with recurrent lung cancer and any insights you might have about these treatment paths. • If you've had treatment for recurrent lung cancer, what was your experience like with the approach you chose? • What helped you feel more prepared or confident as you moved forward with treatment?

What pre-surgery treatments helped shrink your tumor?

My oncologist is discussing treatment options to shrink my tumor before surgery. The possibilities include concurrent chemoradiation, targeted therapy with Osimertinib (osimertinib) if I have certain EGFR mutations, or combinations of immunotherapy like Pembrolizumab (pembrolizumab) with chemotherapy. The final choice will depend on my tumor's genetic testing results and my overall health. I'd love to connect with others who have been through similar pre-surgery treatments and hear about your experiences. • What was your experience with pre-surgery treatment to shrink your tumor? • What helped you prepare for or manage the treatment period before surgery?

Are clinical trials right for stage II lung cancer?

I have Stage II non-small cell lung cancer and had surgery. I've been reading about clinical trials and learned they're not just "last resort" options like I thought. The article I found explains that trials can be considered at different stages of treatment, including early stages, and might provide access to new therapies. I'm realizing there are a lot of myths about clinical trials that I believed. I'd love to hear from others with similar diagnoses about your experiences or thoughts on clinical trials. • Have any of you considered or participated in clinical trials? What was that experience like? • What concerns did you have about clinical trials, and how did you work through them? Link: https://outcomes4me.com/article/clinical-trial-myths/

Outcomes4Me

8 clinical trial myths debunked

Explore 8 common clinical trial myths debunked. Learn the truth about safety, eligibility, and trials to make informed decisions about your

How do I stay hopeful living with stage 4 cancer?

living with cancer: a journey of Hope and humor Diagnosed with stage 4 non small cell cancer back in 2017 I’ve learned that progression free survival means living with regular scans scan anxiety and the ups and downs that comes with treatment. Targeted therapy has its Stone especially the fatigue but I found ways to keep going from grocery runs to work even arguing on social media just to stay sharp! The pandemic added new challenges with personal losses and multiple votes of Covid that affected my hearing still I keep showing up adapting and finding humor in the small victories like stopping for a Dunkin’ Donuts coffee after radiation treatments . In 2024 I face heartbreaking losses for the love and strength from my family especially my wife supporting racing our children kept me grounded she passed away in 2024 from front to temple dementia she was also a physician until the diagnosis was made  Melbourne 2026 I don’t know what the future holds but I focus on good nutrition mode exercise and making at least two people smile each day I even got hearing aids because staying connected matters! Cancel maybe be part of my life but he doesn’t define my spirit to everyone on this path let’s keep wagging our tails, chasing Hope, and living fully . Godspeed best Ramesh

Has anyone used Selpercatinib for RET+ NSCLC?

NSCLC I was diagnosed in January, had surgery in March, completed 30 days radiation and will complete 4 doses of chemo tomorrow. My oncologist wants to include 3 years of Selpercatinib, which is a relatively new RET inhibitor and treats my exact mutation, as a maintenance therapy. Curious if thoughts and results using this treatment?

Does lung surgery pain ever get better after 2 years?

I had a tumor removed by having the bottom lobe of my right lung removed by surgery 2 years ago then done chemo. Still stay in pain does it ever get any better ?

What should I ask my doctor about EGFR-positive lung cancer treatment?

I have stage IV lung adenocarcinoma with an EGFR L858R mutation and haven't started treatment yet. I just read about some promising research from ASCO 2026 discussing new treatment combinations and first-line options for EGFR-positive lung cancer. The article mentions developments in personalized biomarker-driven therapy and new approaches that could be relevant for patients like me who are just beginning their treatment journey. I'd love to connect with others who have a similar diagnosis and hear about your experiences. • What was it like making treatment decisions when you were first diagnosed with EGFR-positive lung cancer? • Are there any questions you wish you had asked your oncology team early on? Link: https://outcomes4me.com/cancer-topic/lung-cancer-research/nsclc-studies-patients-should-be-paying-attention-to-at-asco-2026/

Outcomes4Me

NSCLC studies patients should be paying attention to at ASCO 2026

Discover short summaries of the exciting new non-small cell lung cancer research presented at the 2026 ASCO Annual Meeting.

Has anyone tried the Pfizer PADL1NK 005 clinical trial for lung cancer?

Anyone in Pfizer clinical trial with PADL1NK 005? I had 5 chemos with Keytruda, Carboplatin and taxol, then 27 aditional chemos with Alimta and Keytruda. Cancer turned my world upsidedown in January 2024 when diagnosed with Stage IV NSCLC. I had treatment every 21 days and idled when pet scan this year revealed progresion to C2. Ten sessions of Radiotherapy and kicked off in the Pfizer trial study last week. Praying for strength in this new path.

What to expect after lung cancer surgery: re-resection vs chemo options?

My doctor is discussing next steps after my lung cancer surgery and mentioned two main options: additional surgery (re-resection) to remove any remaining cancer tissue, or drug treatments like chemotherapy or targeted therapy such as Tagrisso (osimertinib) for certain genetic mutations. The choice depends on my surgical results, tumor characteristics, and overall health. I'm trying to understand what to expect with either path and would love to hear from others who faced similar decisions. • If you had re-resection or adjuvant therapy after lung cancer surgery, what was your experience like? • What questions do you wish you had asked your doctor when making this decision?

Does lung cancer treatment cause diarrhea? Looking for tips to manage it

I have non-small cell lung cancer and I'm currently going through treatment. I've been dealing with moderate diarrhea that started recently - this is something new for me. My care team mentioned that digestive changes can happen during cancer treatment, and I'm planning to discuss this with my oncology team. I'd love to connect with others who have experienced similar digestive issues during their lung cancer journey and hear about your experiences. • How did you manage diarrhea during your treatment, and what helped you get through day-to-day activities? • What tips do you wish someone had shared with you when you first experienced digestive changes during treatment?