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In this first part of our four-part series, Dr. Cohen, a medical oncologist, and Dr. Shanahan, patient advocate and president of Metavivor, discuss ESR1 mutations and why they may be an important part of metastatic breast cancer care.
We recently hosted a four-part discussion with Dr. Jules Cohen, a medical oncologist specializing in hematology and oncology at Stony Brook Medicine in New York, and Dr. Kelly Shanahan, a breast cancer survivor (thriver), patient advocate, and president of METAvivor, an organization dedicated to supporting people living with stage 4 metastatic breast cancer.
Together, they break down complex topics in a clear and patient-friendly way to help you feel informed, supported, and empowered throughout your metastatic breast cancer journey.
In this first part of the series, Dr. Cohen and Dr. Shanahan explain what ESR1 mutations are, how they can develop after endocrine therapy, and why testing for ESR1 mutations may be an important step in finding the most effective treatment for you.
Watch to learn:
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what an ESR1 mutation is and how it develops
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who may benefit from ESR1 mutation testing
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how ESR1 mutations can influence treatment decisions
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questions you may want to ask your care team
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where this biomarker fits within the broader landscape of mBC care
Whether you’re newly diagnosed with metastatic breast cancer or navigating a change in treatment, this conversation offers guidance, clarity, and expert insight to help you better understand your options.
Dr. Cohen is a paid consultant of Stemline and this program has been sponsored by Stemline Therapeutics, Inc. Dr. Kelly Shanahan is the President of the Board of Directors of Metavivor, a metastatic breast cancer advocacy organization, that has received sponsorship funding from Stemline Therapeutics, Inc.
IMPORTANT SAFETY INFORMATION
ORSERDU may cause serious side effects, including:
- Increased fat (lipid) levels in your blood (hypercholesterolemia and hypertriglyceridemia). Your healthcare provider will do blood tests to check your lipid levels before and during your treatment with ORSERDU
Before taking ORSERDU, tell your healthcare provider about all your medical conditions, including if you:
- Have liver problems
- Are pregnant or plan to become pregnant. ORSERDU can harm your unborn baby
- Your healthcare provider may do a pregnancy test before you start treatment with ORSERDU
- You should use effective (contraception) birth control during treatment with ORSERDU and for 1 week after the last dose
- Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ORSERDU
- You should use effective (contraception) birth control during treatment with ORSERDU and for 1 week after the last dose
Females who are able to become pregnant:
Males with female partners who are able to become pregnant:
- Are breastfeeding or plan to breastfeed. It is not known if ORSERDU passes into your breast milk. Do not breastfeed during treatment with ORSERDU and for 1 week after the last dose
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ORSERDU and other medicines may affect each other causing side effects. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.
The most common side effects of ORSERDU include:
- Muscle and joint (musculoskeletal) pain
- Nausea
- Increased cholesterol and triglyceride levels in your blood
- Increased liver function tests
- Tiredness
- Decreased red blood cell counts
- Vomiting
- Decreased salt (sodium) levels in your blood
- Increased kidney function test
- Decreased appetite
- Diarrhea
- Headache
- Constipation
- Stomach-area (abdominal) pain
- Hot flush
- Indigestion or heartburn
Your healthcare provider may decrease your dose, temporarily stop, or completely stop treatment with ORSERDU, if you develop certain side effects.
ORSERDU may affect fertility in males and in females who are able to become pregnant. Talk to your healthcare provider if this is a concern for you.
ORSERDU is available as 345 mg and 86 mg tablets.
These are not all the possible side effects of ORSERDU. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.
INDICATION
ORSERDU (elacestrant) is a prescription medicine to treat women who have gone through menopause and adult men with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, ESR1-mutated advanced breast cancer or breast cancer that has spread to other parts of the body (metastatic), and whose disease has progressed after endocrine therapy.
Your healthcare provider will perform a test to make sure that ORSERDU is right for you.
It is not known if ORSERDU is safe and effective in children.
Please see Important Facts about ORSERDU.
Intended for US residents only.