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Part 2: The Emerald Trial

December 2, 2025

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In this second part of our series, Dr. Cohen, a medical oncologist, and Dr. Shanahan, patient advocate and president of Metavivor, break down the EMERALD trial, a pivotal study that evaluated how well ORSERDU works for people with ER+/HER2- metastatic breast cancer.

In this second part of the series, Dr. Cohen and Dr. Shanahan walk through the EMERALD trial, a study that evaluated ORSERDU for people with ER+/HER2- metastatic breast cancer, including individuals who developed ESR1 mutations after endocrine therapy. They describe the purpose of the trial, the study design, who participated, and the outcomes that were observed.

Watch to learn:

  • what the EMERALD trial evaluated and why it was conducted

  • how ORSERDU was studied within the trial

  • which groups of patients were included in the research

  • what outcomes were reported in the study

  • how this trial fits within the broader landscape of metastatic breast cancer research

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Whether you are exploring future treatment options or want to better understand the findings presented in the EMERALD trial, this conversation provides context and expert insight to support informed discussions with your care team.

Dr. Cohen is a paid consultant of Stemline and this program has been sponsored by Stemline Therapeutics, Inc. Dr. Kelly Shanahan is the President of the Board of Directors of Metavivor, a metastatic breast cancer advocacy organization that has been compensated by Outcomes4 me for this project, and has received funding from Stemline Therapeutics, Inc.

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