What is genomic testing and how can it personalize cancer treatment?
Breast cancer treatment is no longer a one-size-fits-all approach. With advancements in personalized medicine, genomic testing has emerged as an important tool in tailoring treatment plans to individual patients. By analyzing the DNA of a tumor, genomic testing can identify specific mutations or biomarkers that may influence its response to therapy, leading to more effective and targeted treatment options.
Genomic testing in HR+/HER2- metastatic breast cancer
For patients with HR+/HER2- metastatic breast cancer (mBC), genomic testing can be particularly valuable. This type of breast cancer is often treated with hormone therapies and targeted therapies. Genomic testing can provide additional insights that can further personalize treatment.
For example, the detection of a PIK3CA gene mutation, which is common in HR+/HER2- breast cancer, may indicate that a patient could benefit from a drug that specifically targets this mutation. Genomic testing can also identify mechanisms of resistance to hormone treatment, allowing doctors to adjust treatment strategies and potentially improve outcomes.
The benefits of genomic testing
- Personalized treatment: Genomic testing allows for the selection of therapies that are most likely to be effective based on the specific genetic alterations present in the tumor.
- Improved outcomes: By targeting the unique characteristics of the cancer, genomic testing can potentially lead to improved treatment responses and better outcomes.
- Proactive management of resistance: Genomic testing can identify potential mechanisms of resistance, allowing doctors to adjust treatment strategies early and prevent or delay disease progression.
- Access to clinical trials: Genomic testing can identify patients who may be eligible for clinical trials that are evaluating new therapies for specific genomic alterations.
Taking the next step: Discussing genomic testing with your oncologist
If you received a HR+/HER2- mBC diagnosis, it’s important to talk to your oncologist about genomic testing. Discuss whether this testing is appropriate for your specific situation and explore how the results could potentially impact your treatment options and future decisions.
Remember, knowledge is power. Understanding the genetic profile of your cancer empowers you to make informed decisions about your treatment and helps your healthcare team develop a personalized plan.
Connect with an Outcomes4Me oncology nurse practitioner at no charge through the Outcomes4Me app, using the “Ask Outcomes4Me” button.
