CDK4/6 inhibitors with hormone therapy for HR+ metastatic breast cancer?
Community Member
3 days agoI have HR-positive, HER2-negative metastatic breast cancer and I'm currently on first-line treatment with fulvestrant alone. I recently learned about CDK4/6 inhibitors like palbociclib, ribociclib, and abemaciclib being combined with hormone therapy for my type of cancer. My oncologist and I may discuss these combinations for future treatment options if my current therapy needs adjustment. I'd love to connect with others who have a similar diagnosis and have experience with CDK4/6 inhibitor combinations. • If you've used a CDK4/6 inhibitor with hormone therapy, what was your experience like day to day? • What do you wish you had known before starting combination treatment? Link: https://d218mh3sadleh5.cloudfront.net/Clients/Stemline/Orserdu/ORSERDU_DTP_Important_Facts_Document.pdfy
Community Member
3 days agoCDK4/6 inhibitors combined with hormone therapy have shown promising results for HR-positive, HER2-negative metastatic breast cancer in clinical studies. The community members here who have experience with these combination treatments can offer valuable insights about the day-to-day realities and practical tips that might help as treatment decisions are considered with an oncologist.
Community Member
2 days agoI My first line of treatment was Kisquali and fluvestrant and I had good results shrinking. The tumor in my breast and dissolving most of my lung nodules.
Community Member
2 days agoI have the same type of breast cancer and mine is Grade 3. I think this combination is a good way to begin. And see results. Talk to your doctor.
Community Member
2 days agoI have mBC with bone and lymph nodes. I took lbrance with fluvestrant for 7 1/2 years as my 1st line of therapy. The only side effect was constipation with explosive diarrhea. Taking stool softener and extra water took care of it. Then, my cancer developed a cancer mutation PTEN/AKT. Truqap with fluvestrant started working, but the diarrhea was bad so I stopped. I'll restart soon at a lower dose and hope I'll respond better. I'm now a 10 1/2 year survivor. Praying you will have many years of disease free progression.
New to the community?
Create an account to connect with others navigating cancer.
Related Questions
- How often should CDK 4/6 inhibitors like Ibrance be monitored?
- Switching Between Different CDK 4/6 Inhibitors?
- Has Anyone Taken Kisqali (Ribociclib)?
- Seeking Experiences: Stage IV Breast Cancer on Enhertu Treatment
- Has anyone with mbc and pleural effusion received endocrine therapy or chemo?
- Is Ibrance gentler than Verzenio for an 80-year-old with MBC?
- CDK4/6 inhibitors with hormone therapy for HR+ metastatic breast cancer?
- CDK4/6 inhibitors with hormone therapy for HR+ metastatic breast cancer?
© 2026 Outcomes4Me Inc. All rights reserved.