If you are diagnosed with metastatic breast cancer, one of the first things you’ll likely hear is that it’s not curable. That understanding has shaped how patients and doctors think about stage IV breast cancer for decades. But for a small group of patients, especially those with HER2-positive disease, the possibility of being treated with […]

Each December, the prestigious San Antonio Breast Cancer Symposium (SABCS) unites the breast cancer community to discuss the latest innovations and future directions of MBC care. SABCS 2025 included several important updates for metastatic breast cancer across hormone-positive, HER2-positive, HER2-low, and triple-negative disease. Here are the 7 highlights that stood out most for patients. 1) […]

October 13th marks Metastatic Breast Cancer Awareness Day, a day dedicated to amplifying the voices, stories, and challenges of people living with metastatic breast cancer. Sexual health and body image are often left out of the dialogue, but they are essential parts of quality of life. We asked Fox Chase Cancer Center’s Dr. Jennifer Reese […]

Bone is the most common site for breast cancer to spread when it becomes metastatic. Up to 70% of people with metastatic breast cancer will develop bone metastases most often affecting the spine, ribs, and pelvis. While it’s not possible to cure bone metastases, there are many treatments and lifestyle factors available that can help […]

Palliative care for metastatic breast cancer: What you need to know Palliative care is a specialized field that helps improve the quality of life for anyone facing a serious illness. Sometimes confused with hospice care, palliative care can begin at any point after a diagnosis, whereas hospice care is focused on end-of-life care without a […]

CDK 4/6 inhibitor side effects, treatment length, and more Dr. Pooja Advani is a breast oncologist and the Director of the Robert and Monica Jacoby Center for Breast Health at Mayo Clinic, Jacksonville. In a recent interview, we asked Dr. Advani about CDK4/6 inhibitors and how they can support patients with hormone receptor-positive, HER2-negative, metastatic […]

Enhertu (fam-trastuzumab deruxtecan-nxki or T-DXd) has shown promising results in slowing down or stopping the growth of certain types of breast cancer, regardless of whether patients have specific gene changes, according to a presentation from the 2025 ASCO Annual Meeting. In an exploratory analysis of the phase 3 DESTINY-Breast06 trial, treatment with Enhertu (fam-trastuzumab deruxtecan-nxki; […]

Learn the 7 early warning signs of metastatic breast cancer, including pain, fatigue, and new symptoms. Spot the red flags early and take action.

Improving treatment outcomes in HR+ metastatic breast cancer If you’re living with hormone receptor-positive (HR+) metastatic breast cancer (mBC), you’ve likely heard about hormone therapy. Hormone therapies, also called endocrine therapies, are the foundation of treatment for this type of breast cancer. These treatments work by blocking estrogen, the hormone that helps HR+ breast cancer […]

 CDK 4/6 inhibitors: Monitoring effectiveness and resistance For patients with hormone receptor-positive, HER2-negative, metastatic breast cancer, CDK 4/6 inhibitors in combination with hormone-blocking therapy is the frontline treatment option. In our interview with Dr. Pooja Advani, we explore the latest advancements in CDK 4/6 inhibitors and what to expect while you’re on treatment. Dr. Advani […]

What is HR+ metastatic breast cancer? When you hear the words hormone receptor-positive metastatic breast cancer (HR+ mBC), it can feel overwhelming. Let’s break that diagnosis down: Hormone Receptor-Positive (HR+) means that the breast cancer cells have receptors (like “docking stations”) for estrogen or progesterone — hormones that help the cancer grow. Metastatic means the […]

What is next-generation sequencing and how does it work in guiding breast cancer treatment? During a recent webinar that we hosted with Dr. Sara Hurvitz of Fred Hutch Cancer Center, we explored the topic of next-generation sequencing, or NGS. Read on to learn more about this type of breast cancer testing and why it matters for […]